Document Detail


Photoluminescent DNA binding and cytotoxic activity of a platinum(II) complex bearing a tetradentate β-diketiminate ligand.
MedLine Citation:
PMID:  23143731     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A platinum(II) complex of a monoanionic, tetradentate β-diketiminate (BDI) ligand with pendant quinoline arms, BDI(QQ)H, is reported. The complex, [Pt(BDI(QQ))]Cl, is emissive in DMSO, but non-emissive in aqueous buffer. Upon binding DNA in buffer, however, a 150-fold turn-on in emission intensity occurs. Dynamic light scattering and (1)H NMR spectroscopy indicate that [Pt(BDI(QQ))]Cl forms non-emissive aggregates in aqueous solution; DNA-binding disperses the aggregates leading to the large emission turn-on response. The cytotoxic activity of the complex, measured in two cancer cell lines, is comparable to or better than that of the established anticancer drug cisplatin.
Authors:
Jennifer M Hope; Justin J Wilson; Stephen J Lippard
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-11-12
Journal Detail:
Title:  Dalton transactions (Cambridge, England : 2003)     Volume:  42     ISSN:  1477-9234     ISO Abbreviation:  Dalton Trans     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-06     Completed Date:  2013-07-29     Revised Date:  2014-03-09    
Medline Journal Info:
Nlm Unique ID:  101176026     Medline TA:  Dalton Trans     Country:  England    
Other Details:
Languages:  eng     Pagination:  3176-80     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Antineoplastic Agents / chemistry,  metabolism*,  pharmacology*
DNA / metabolism*
HeLa Cells
Humans
Imines / chemistry*
Ligands
Light*
Models, Molecular
Molecular Conformation
Nitriles / chemistry*
Organoplatinum Compounds / chemistry,  metabolism*,  pharmacology*
Grant Support
ID/Acronym/Agency:
1S10RR13886/RR/NCRR NIH HHS; CA034992/CA/NCI NIH HHS; R01 CA034992/CA/NCI NIH HHS; R37 CA034992/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/Imines; 0/Ligands; 0/Nitriles; 0/Organoplatinum Compounds; 0/ketimine; 9007-49-2/DNA
Comments/Corrections

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