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Photoletter to the editor: Localized pyoderma gangrenosum after interferon-alpha2b injections.
MedLine Citation:
PMID:  23091590     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
We present a male patient with polycythemia vera (PV) in whom pyoderma gangrenosum (PG) was induced by subcutaneous injections of interferon-α2beta (IFN-α2b).The patient presented with a 6 cm wide necrotic ulcer on the external aspect of his left thigh, which was surrounded by an erythematous and indurated plaque. He also had a simetrical but smaller 2 cm of size ulcer on the external aspect of the right thigh. Histopathological examination showed a massive perivascular and interstitial inflammatory infiltrate. It was vastly composed of neutrophils and secondary formation of interstitial neutrophilic microabscesses was also observed.To our knowledge only two cases of PG secondary to IFN-α2b injections have been reported, none of them in a patient with PV. Physicians should be aware of these IFN-α2b-related local adverse effects as they might become extremely severe. Immediate local discontinuation of drug administration is mandatory. In order to avoid these complications, alternating injection sites is highly advisable.
Authors:
José M Mir-Bonafé; Susana Blanco-Barrios; Alberto Romo-Melgar; Angel Santos-Briz; Emilia Fernández-López
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of dermatological case reports     Volume:  6     ISSN:  1898-7249     ISO Abbreviation:  J Dermatol Case Rep     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-10-23     Completed Date:  2012-10-24     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  101493700     Medline TA:  J Dermatol Case Rep     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  98-9     Citation Subset:  -    
Affiliation:
Department of Dermatology, University Hospital of Salamanca, Paseo de San Vicente 58-182, 37007, Salamanca, Spain.
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