Document Detail

Photodynamic treatment of oral lichen planus.
MedLine Citation:
PMID:  23217536     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: The aim of this study was to examine the clinical behavior and response to topical methyl 5-aminolevulinate (MAL) photodynamic therapy (PDT) of oral lichen planus and to describe the buildup and biodistribution of photoactive porphyrins in normal and lichen planus-affected oral mucosa after MAL application.
STUDY DESIGN: The difference in clinical expression in 14 patients with buccal oral lichen planus was compared before and after treatment. MAL-induced photoactive porphyrins were monitored using noninvasive in situ fluorescence measurements. Microfluorometry was used to study the biodistribution.
RESULTS: The absorption and conversion of protoporphyrin IX (PpIX) in epithelial and subepithelial T cells was demonstrated in histologic sections. As a result of 1 treatment session, there was a significant improvement of oral lichen planus after 6 months (P = 0.02) and during a 4-year follow-up period.
CONCLUSIONS: MAL is absorbed and converted to PpIX in T cells. Oral lichen planus treated with MAL-PDT showed lasting improvement after a single treatment.
Sigrid I Kvaal; Even Angell-Petersen; Trond Warloe
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Oral surgery, oral medicine, oral pathology and oral radiology     Volume:  115     ISSN:  2212-4411     ISO Abbreviation:  Oral Surg Oral Med Oral Pathol Oral Radiol     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-11     Completed Date:  2013-05-24     Revised Date:  2014-02-27    
Medline Journal Info:
Nlm Unique ID:  101576782     Medline TA:  Oral Surg Oral Med Oral Pathol Oral Radiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  62-70     Citation Subset:  D; IM    
Copyright Information:
Copyright © 2013 Elsevier Inc. All rights reserved.
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MeSH Terms
Aminolevulinic Acid / analogs & derivatives*,  therapeutic use
Lichen Planus, Oral / drug therapy*
Photochemotherapy / methods*
Photosensitizing Agents / therapeutic use*
Prospective Studies
Treatment Outcome
Reg. No./Substance:
0/Photosensitizing Agents; 0/methyl 5-aminolevulinate; 88755TAZ87/Aminolevulinic Acid
Comment In:
Oral Surg Oral Med Oral Pathol Oral Radiol. 2014 Feb;117(2):257-8   [PMID:  24439922 ]
Oral Surg Oral Med Oral Pathol Oral Radiol. 2014 Feb;117(2):257   [PMID:  24182596 ]

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