Document Detail

Photodynamic therapy with delta-aminolevulinic acid and light-emitting diodes in actinic keratosis.
MedLine Citation:
PMID:  21152788     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Photodynamic therapy is a form of treatment in which a photosensitizing substance is applied to tissue and activated by a light source at a specific wavelength, thus selectively destroying cells. New light sources are being evaluated for use in the treatment of actinic keratoses.
OBJECTIVES: To evaluate the efficacy of photodynamic therapy with delta-aminolevulinic acid using a light emitting diode device as a light source in the treatment of actinic keratoses of the face and upper limbs.
METHODS: Eighteen patients with actinic keratoses of the face or upper limbs received an application of a 20% delta-aminolevulinic acid cream and were submitted to diode light irradiation at a wavelength of 630 nm.
RESULTS: A total of 328 actinic keratoses were treated, obtaining complete cure in 210 (64.0%) after 24 weeks. Lesions situated on the back of the hands were clinically cured in 49.2% of cases compared to 81.4% in the cases of lesions in other areas. There was no record of any severe adverse effects and patient satisfaction with the results was high.
CONCLUSION: Photodynamic therapy with a diode light emitting source proved effective and well-tolerated for the treatment of actinic keratoses, with results similar to those reported in the literature with other light sources.
Clarice Gabardo Ritter; Isabel Cristina Palma Kuhl; Carolina Lenhardt; Marlene Laks Weissbluth; Renato Marchiori Bakos
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anais brasileiros de dermatologia     Volume:  85     ISSN:  1806-4841     ISO Abbreviation:  An Bras Dermatol     Publication Date:    2010 Sep-Oct
Date Detail:
Created Date:  2010-12-14     Completed Date:  2011-10-18     Revised Date:  2012-08-20    
Medline Journal Info:
Nlm Unique ID:  0067662     Medline TA:  An Bras Dermatol     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  639-45     Citation Subset:  IM    
Porto Alegre Teaching Hospital, Federal University of Rio Grande do Sul, RS, Brazil.
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MeSH Terms
Aged, 80 and over
Aminolevulinic Acid / adverse effects,  therapeutic use*
Facial Dermatoses / drug therapy
Follow-Up Studies
Keratosis, Actinic / drug therapy*
Middle Aged
Patient Satisfaction
Photochemotherapy / methods*
Photosensitizing Agents / adverse effects,  therapeutic use*
Treatment Outcome
Reg. No./Substance:
0/Photosensitizing Agents; 106-60-5/Aminolevulinic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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