| Photodynamic therapy with 5-aminolevulinic acid and diamino acid derivatives of protoporphyrin IX reduces papillomas in mice without eliminating transformation into squamous cell carcinoma of the skin. | |
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MedLine Citation:
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PMID: 19521986 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Photodynamic therapy (PDT) is used to treat malignant and nonmalignant diseases. It is also used for cosmetological skin treatment. PDT is generally considered to have a low risk of carcinogenicity. However, instances of nonmalignant human tumors turning malignant have been linked to PDT. In this study, we used 5-aminolevulinic (ALA) acid and 3 water soluble photosensitizers-PP(Arg)(2), PP(Ser)(2)Arg(2), PP(Ala)(2)Arg(2), all diamino acid derivatives of protoporphyrin IX-to treat benign papillomas in FVB/N mice induced by 7,12-dimethylbenz(a)anthracene (DMBA)-12-O-tetradecanoyl-phorbol-13-acetate (TPA). Of these drugs, ALA and PP(Arg)(2) were found the most efficient. PDT reduced the number of papillomas, but with increasing effectiveness of the drugs, the risk of malignant transformation of the papillomas into squamous cell carcinomas increased. The underlying mechanisms are not clear and further investigations are needed. |
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Authors:
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Mateusz Kwitniewski; Dawid Jankowski; Kazimierz Jaskiewicz; Halina Dziadziuszko; Asta Juzeniene; Johan Moan; Li-Wei Ma; Rafal Peksa; Danuta Kunikowska; Alfreda Graczyk; Miroslaw Kwasny; Miron Kaliszewski; Renata Glosnicka |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International journal of cancer. Journal international du cancer Volume: 125 ISSN: 1097-0215 ISO Abbreviation: Int. J. Cancer Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-08-05 Completed Date: 2009-08-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0042124 Medline TA: Int J Cancer Country: United States |
Other Details:
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Languages: eng Pagination: 1721-7 Citation Subset: IM |
Affiliation:
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Department of Molecular Microbiology and Serology, National Salmonella Centre, Medical University of Gdansk, Gdansk, Poland. kwitniewski@amg.gda.pl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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9,10-Dimethyl-1,2-benzanthracene Aminolevulinic Acid / therapeutic use* Animals Carcinogens Carcinoma, Squamous Cell / etiology* Cell Transformation, Neoplastic / pathology* Kaplan-Meiers Estimate Mice Mice, Inbred Strains Papilloma / chemically induced, complications, drug therapy* Photochemotherapy / methods* Photosensitizing Agents / therapeutic use* Protoporphyrins / therapeutic use* Skin Neoplasms / chemically induced, drug therapy*, etiology* Tetradecanoylphorbol Acetate |
| Chemical | |
Reg. No./Substance:
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0/Carcinogens; 0/Photosensitizing Agents; 0/Protoporphyrins; 106-60-5/Aminolevulinic Acid; 16561-29-8/Tetradecanoylphorbol Acetate; 553-12-8/protoporphyrin IX; 57-97-6/9,10-Dimethyl-1,2-benzanthracene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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