Document Detail

Photodynamic therapy with 5-aminolevulinic acid and diamino acid derivatives of protoporphyrin IX reduces papillomas in mice without eliminating transformation into squamous cell carcinoma of the skin.
MedLine Citation:
PMID:  19521986     Owner:  NLM     Status:  MEDLINE    
Photodynamic therapy (PDT) is used to treat malignant and nonmalignant diseases. It is also used for cosmetological skin treatment. PDT is generally considered to have a low risk of carcinogenicity. However, instances of nonmalignant human tumors turning malignant have been linked to PDT. In this study, we used 5-aminolevulinic (ALA) acid and 3 water soluble photosensitizers-PP(Arg)(2), PP(Ser)(2)Arg(2), PP(Ala)(2)Arg(2), all diamino acid derivatives of protoporphyrin IX-to treat benign papillomas in FVB/N mice induced by 7,12-dimethylbenz(a)anthracene (DMBA)-12-O-tetradecanoyl-phorbol-13-acetate (TPA). Of these drugs, ALA and PP(Arg)(2) were found the most efficient. PDT reduced the number of papillomas, but with increasing effectiveness of the drugs, the risk of malignant transformation of the papillomas into squamous cell carcinomas increased. The underlying mechanisms are not clear and further investigations are needed.
Mateusz Kwitniewski; Dawid Jankowski; Kazimierz Jaskiewicz; Halina Dziadziuszko; Asta Juzeniene; Johan Moan; Li-Wei Ma; Rafal Peksa; Danuta Kunikowska; Alfreda Graczyk; Miroslaw Kwasny; Miron Kaliszewski; Renata Glosnicka
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of cancer. Journal international du cancer     Volume:  125     ISSN:  1097-0215     ISO Abbreviation:  Int. J. Cancer     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-08-05     Completed Date:  2009-08-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0042124     Medline TA:  Int J Cancer     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1721-7     Citation Subset:  IM    
Department of Molecular Microbiology and Serology, National Salmonella Centre, Medical University of Gdansk, Gdansk, Poland.
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MeSH Terms
Aminolevulinic Acid / therapeutic use*
Carcinoma, Squamous Cell / etiology*
Cell Transformation, Neoplastic / pathology*
Kaplan-Meiers Estimate
Mice, Inbred Strains
Papilloma / chemically induced,  complications,  drug therapy*
Photochemotherapy / methods*
Photosensitizing Agents / therapeutic use*
Protoporphyrins / therapeutic use*
Skin Neoplasms / chemically induced,  drug therapy*,  etiology*
Tetradecanoylphorbol Acetate
Reg. No./Substance:
0/Carcinogens; 0/Photosensitizing Agents; 0/Protoporphyrins; 106-60-5/Aminolevulinic Acid; 16561-29-8/Tetradecanoylphorbol Acetate; 553-12-8/protoporphyrin IX; 57-97-6/9,10-Dimethyl-1,2-benzanthracene

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