| Photodynamic therapy using verteporfin-induced minimal change nephrotic syndrome. | |
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MedLine Citation:
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PMID: 12470762 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To report a case of minimal change nephrotic syndrome (MCNS) after photodynamic therapy using verteporfin. DESIGN: Interventional case report. METHODS: After four cycles of photodynamic therapy, general weakness with generalized edema developed in an otherwise healthy 66-year-old woman, resulting in dyspnea and ascites. Urinalysis showed heavy proteinuria (4+) with decreased serum total protein and albumin, and increased total cholesterol levels, suggesting nephrotic syndrome. Renal biopsy and pathologic diagnosis were performed. RESULTS: Renal biopsy revealed normal glomeruli and tubulointerstitium by light microscopy, with no immunoglobin or complement deposition. Transmission electron microscopy showed diffuse effacement of the foot processes of visceral epithelial cells, which is the characteristic finding of minimal change nephrotic syndrome. CONCLUSIONS: We herein report a case of minimal change nephrotic syndrome after photodynamic therapy using verteporfin. |
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Authors:
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Shin W Kang; Shin J Kang; Hyun O Kim; Eun S Nam; Jin H Lee; Hyoung J Koh |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: American journal of ophthalmology Volume: 134 ISSN: 0002-9394 ISO Abbreviation: Am. J. Ophthalmol. Publication Date: 2002 Dec |
Date Detail:
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Created Date: 2002-12-09 Completed Date: 2003-01-02 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0370500 Medline TA: Am J Ophthalmol Country: United States |
Other Details:
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Languages: eng Pagination: 907-8 Citation Subset: AIM; IM |
Affiliation:
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Department of Internal Medicine, Institute of Kidney Disease, Yonsei University College of Medicine, Sodaemun-gu, Seoul, South Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Biopsy Blood Proteins / metabolism Cholesterol / blood Choroidal Neovascularization / diagnosis, drug therapy Female Fluorescein Angiography Humans Kidney / pathology Nephrosis, Lipoid / chemically induced*, diagnosis Photochemotherapy / adverse effects* Photosensitizing Agents / adverse effects* Porphyrins / adverse effects* Proteinuria / diagnosis |
| Chemical | |
Reg. No./Substance:
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0/Blood Proteins; 0/Photosensitizing Agents; 0/Porphyrins; 129497-78-5/verteporfin; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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