Document Detail


Photodynamic therapy of necrobiosis lipoidica--a multicenter study of 18 patients.
MedLine Citation:
PMID:  19060464     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Necrobiosis lipoidica (NL) is a granulomatous skin disease of unknown origin, and no reliably effective treatment option exists to handle this often disfiguring disease. Recently, a patient with long-lasting NL was reported to be cured by topical photodynamic therapy (PDT). OBJECTIVE: To evaluate the overall potential of PDT in the treatment of NL on the lower legs. METHODS: Retrospective study of 18 patients (aged 16-62 years) from 3 European university departments of dermatology treated with PDT for NL. Methyl aminolevulinate or 5-aminolevulinic acid were used as topically applied photosensitizers. Illumination followed with red light-emitting diode light. RESULTS: Complete response was seen in 1/18 patients after 9 PDT cycles, and partial response in 6/18 patients (2-14 PDT cycles) giving an overall response rate of 39% (7/18). CONCLUSION: Although almost 40% of the cases showed some degree of response, PDT cannot currently be recommended as first-line therapy of NL. Subpopulations of therapy-resistant NL patients may, however, benefit from PDT.
Authors:
C Berking; J Hegyi; P Arenberger; T Ruzicka; G B E Jemec
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Publication Detail:
Type:  Journal Article; Multicenter Study     Date:  2008-12-06
Journal Detail:
Title:  Dermatology (Basel, Switzerland)     Volume:  218     ISSN:  1421-9832     ISO Abbreviation:  Dermatology (Basel)     Publication Date:  2009  
Date Detail:
Created Date:  2009-01-29     Completed Date:  2009-06-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9203244     Medline TA:  Dermatology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  136-9     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2008 S. Karger AG, Basel.
Affiliation:
Department of Dermatology, Ludwig Maximilian University, Frauenlobstrasse 9-11, Munich, Germany. Carola.Berking@med.uni-muenchen.de
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MeSH Terms
Descriptor/Qualifier:
Administration, Cutaneous
Adolescent
Adult
Aminolevulinic Acid / administration & dosage,  analogs & derivatives*
Czech Republic
Denmark
Female
Germany
Humans
Leg / pathology
Male
Middle Aged
Necrobiosis Lipoidica / drug therapy*,  pathology
Photochemotherapy / methods*
Photosensitizing Agents / administration & dosage*
Retrospective Studies
Treatment Outcome
Chemical
Reg. No./Substance:
0/Photosensitizing Agents; 0/methyl 5-aminolevulinate; 106-60-5/Aminolevulinic Acid

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