| Photodynamic therapy of necrobiosis lipoidica--a multicenter study of 18 patients. | |
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MedLine Citation:
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PMID: 19060464 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Necrobiosis lipoidica (NL) is a granulomatous skin disease of unknown origin, and no reliably effective treatment option exists to handle this often disfiguring disease. Recently, a patient with long-lasting NL was reported to be cured by topical photodynamic therapy (PDT). OBJECTIVE: To evaluate the overall potential of PDT in the treatment of NL on the lower legs. METHODS: Retrospective study of 18 patients (aged 16-62 years) from 3 European university departments of dermatology treated with PDT for NL. Methyl aminolevulinate or 5-aminolevulinic acid were used as topically applied photosensitizers. Illumination followed with red light-emitting diode light. RESULTS: Complete response was seen in 1/18 patients after 9 PDT cycles, and partial response in 6/18 patients (2-14 PDT cycles) giving an overall response rate of 39% (7/18). CONCLUSION: Although almost 40% of the cases showed some degree of response, PDT cannot currently be recommended as first-line therapy of NL. Subpopulations of therapy-resistant NL patients may, however, benefit from PDT. |
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Authors:
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C Berking; J Hegyi; P Arenberger; T Ruzicka; G B E Jemec |
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Publication Detail:
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Type: Journal Article; Multicenter Study Date: 2008-12-06 |
Journal Detail:
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Title: Dermatology (Basel, Switzerland) Volume: 218 ISSN: 1421-9832 ISO Abbreviation: Dermatology (Basel) Publication Date: 2009 |
Date Detail:
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Created Date: 2009-01-29 Completed Date: 2009-06-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9203244 Medline TA: Dermatology Country: Switzerland |
Other Details:
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Languages: eng Pagination: 136-9 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2008 S. Karger AG, Basel. |
Affiliation:
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Department of Dermatology, Ludwig Maximilian University, Frauenlobstrasse 9-11, Munich, Germany. Carola.Berking@med.uni-muenchen.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Cutaneous Adolescent Adult Aminolevulinic Acid / administration & dosage, analogs & derivatives* Czech Republic Denmark Female Germany Humans Leg / pathology Male Middle Aged Necrobiosis Lipoidica / drug therapy*, pathology Photochemotherapy / methods* Photosensitizing Agents / administration & dosage* Retrospective Studies Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Photosensitizing Agents; 0/methyl 5-aminolevulinate; 106-60-5/Aminolevulinic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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