Document Detail

Photodynamic therapy mediated by methylene blue dye in wound healing.
MedLine Citation:
PMID:  20961226     Owner:  NLM     Status:  In-Process    
OBJECTIVE: We sought to investigate the wound-healing process after photodynamic therapy (PDT) mediated by methylene blue dye (MB).
BACKGROUND DATA: Few scientific studies show the PDT roles in wound healing.
MATERIALS AND METHODS: One hundred rats were given a circular wound on the back, inflicted with a 6-mm-diameter punch. The animals were divided into four groups: control (no treatment); dye (topical application of MB); laser (InGaAlP, 117.85 J/cm(2), 100 mW, 660 nm, single point); and PDT (topical application of MB followed by laser irradiation). After 1, 3, 5, 7, and 14 days, the cutaneous wounds were photographed and assessed with histopathologic examination by using light microscope. Changes seen in edema, necrosis, inflammation, granulation tissue, re-epithelialization, and number of young fibroblasts were semiquantitatively evaluated. The wound-area changes were measured with special software and submitted to statistical analysis.
RESULTS: The laser group demonstrated the smallest wound area at 14 days after the surgical procedure (p < 0.01). Concerning complete re-epithelialization, the laser group showed it at 5-7 days after surgery, whereas the PDT and the other groups showed it at 14 days.
CONCLUSIONS: Laser interaction with tissue is somehow changed when exposed to the MB. PDT mediated by MB was not prejudicial to wound healing, as no delay occurred compared with the control group.
Felipe Fornias Sperandio; Alyne Simões; Ana Cecília Corrêa Aranha; Luciana Corrêa; Suzana C Orsini Machado de Sousa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Photomedicine and laser surgery     Volume:  28     ISSN:  1557-8550     ISO Abbreviation:  Photomed Laser Surg     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101222340     Medline TA:  Photomed Laser Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  581-7     Citation Subset:  IM    
Department of Oral Pathology, School of Dentistry, University of São Paulo, Brazil.
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