Document Detail


Photodynamic therapy for localised prostatic cancer: light penetration in the human prostate gland.
MedLine Citation:
PMID:  2299739     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We are investigating the feasibility of photodynamic therapy in the treatment of localised prostatic cancer. Of major importance in this form of treatment is the extent to which light penetrates the target organ; hence, our interest in the optical properties of the human prostate gland. We obtained three whole prostates from autopsies of patients who died of non-urological causes. Red light was launched interstitially and detector fibres measured light intensity as a function of distance from the delivery fibre end. The optical constants derived from the three prostates were almost identical and indicated that light was predominantly scattered rather than absorbed (mean absorption and scattering coefficients 0.07 +/- 0.02 mm.-1 and 0.86 +/- 0.05 mm.-1 respectively). In a comparison of the tissue penetration by four different wavelengths, 633 nm red light was found to be transmitted best. Light propagation in the heavily absorbing tissue of the human liver was 4.3 times poorer than in the prostate. Such a combination of low absorption and high scattering characteristics in prostatic tissue would enhance the effectiveness of PDT. The optical constants derived will enable "light treatment planning" in patients with prostatic cancer.
Authors:
M L Pantelides; C Whitehurst; J V Moore; T A King; N J Blacklock
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of urology     Volume:  143     ISSN:  0022-5347     ISO Abbreviation:  J. Urol.     Publication Date:  1990 Feb 
Date Detail:
Created Date:  1990-02-27     Completed Date:  1990-02-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376374     Medline TA:  J Urol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  398-401     Citation Subset:  AIM; IM    
Affiliation:
University Department of Urology, University Hospital of South Manchester, United Kingdom.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Humans
Light
Male
Photochemotherapy*
Prostate*
Prostatic Neoplasms / drug therapy*
Scattering, Radiation*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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