Document Detail

Photodynamic therapy of circumscribed choroidal haemangioma.
MedLine Citation:
PMID:  15489484     Owner:  NLM     Status:  MEDLINE    
AIM: To evaluate efficacy of verteporfin ocular photodynamic therapy (PDT) in treatment of 10 patients with a symptomatic circumscribed choroidal haemangioma.
DESIGN: Prospective non-randomised, interventional case series and critical review of previously published studies.
METHODS: 10 consecutive patients (seven primary, two failed transpupillary thermotherapy (TTT), and one failed external beam radiotherapy) with symptomatic circumscribed choroidal haemangioma were treated using verteporfin 6 mg/m2 given as an intravenous infusion over 10 minutes. Diode laser (690 nm) with an intensity of 600 mW/cm2 for 83 seconds (50 J/cm2) was applied 5 minutes after completion of infusion. Single or multiple partially overlapping spots were applied based on the tumour basal dimensions. Periodic follow up with ophthalmoscopy, ultrasonography, and angiographic studies was performed.
RESULTS: All 10 patients showed evidence of regression with flattening of tumour, resolution of subretinal fluid, and reduction of choroidal vasculature on angiograms. The visual acuity either improved or remained stable in eight (80%) patients. Visual loss due to delayed choroidal atrophy was seen in two patients.
CONCLUSIONS: Although verteporfin PDT is an effective treatment for management of symptomatic circumscribed choroidal haemangioma, delayed treatment related effects can lead to visual loss.
A D Singh; P K Kaiser; J E Sears; M Gupta; P A Rundle; I G Rennie
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The British journal of ophthalmology     Volume:  88     ISSN:  0007-1161     ISO Abbreviation:  Br J Ophthalmol     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2004-10-18     Completed Date:  2004-11-22     Revised Date:  2013-06-09    
Medline Journal Info:
Nlm Unique ID:  0421041     Medline TA:  Br J Ophthalmol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1414-8     Citation Subset:  IM    
Department of Ophthalmic Oncology, Cole Eye Institute (i3-129), Cleveland Clinic Foundation, 9500 Euclid Avenue, OH 44195, USA.
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MeSH Terms
Choroid Neoplasms / drug therapy*,  pathology
Fluorescein Angiography
Hemangioma / drug therapy*,  pathology
Middle Aged
Photochemotherapy / methods*
Photosensitizing Agents / therapeutic use*
Porphyrins / therapeutic use*
Prospective Studies
Treatment Outcome
Reg. No./Substance:
0/Photosensitizing Agents; 0/Porphyrins; 129497-78-5/verteporfin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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