Document Detail


Photodynamic therapy by topical meso-tetraphenylporphinesulfonate tetrasodium salt administration in superficial basal cell carcinomas.
MedLine Citation:
PMID:  2369729     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The efficacy of an originally developed photodynamic approach, using topical administration of tetraphenylporphinesulfonate as the photosensitizer, was evaluated in a series of 292 basal cell carcinoma lesions (less than 2-mm thick) in 50 treated patients. The lack of indication for conventional therapies was the main selection criterion. The photosensitizing agent (2% solution) was topically applied at 0.1 ml/cm2, followed by light irradiation with a dye laser emitting at 645 nm (120 or 150 J/cm2). After initial treatment, all lesions responded, with 273 (93.5%) complete responses. Recurrences were observed in 29 (10.6%). A second application of photoradiation was performed in 15 persistent lesions and 11 relapsed lesions, producing 19/26 complete responses. Our results suggest that this technique can be considered a promising alternative treatment modality in selected cases of superficial basal cell carcinomas.
Authors:
O Santoro; G Bandieramonte; E Melloni; R Marchesini; F Zunino; P Lepera; G De Palo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cancer research     Volume:  50     ISSN:  0008-5472     ISO Abbreviation:  Cancer Res.     Publication Date:  1990 Aug 
Date Detail:
Created Date:  1990-08-23     Completed Date:  1990-08-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2984705R     Medline TA:  Cancer Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  4501-3     Citation Subset:  IM    
Affiliation:
Department of Diagnostic Oncology, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy.
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MeSH Terms
Descriptor/Qualifier:
Aged
Biopsy
Carcinoma, Basal Cell / drug therapy*,  pathology
Follow-Up Studies
Humans
Photochemotherapy*
Porphyrins / therapeutic use*
Radiation-Sensitizing Agents / therapeutic use*
Skin Neoplasms / drug therapy*,  pathology
Chemical
Reg. No./Substance:
0/Porphyrins; 0/Radiation-Sensitizing Agents; 35218-75-8/tetraphenylporphine sulfonate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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