Document Detail

Photodynamic effect of lanthanide derivatives of meso-tetra(N-methyl-4-pyridyl)porphine against Staphylococcus aureus.
MedLine Citation:
PMID:  18726009     Owner:  NLM     Status:  MEDLINE    
Photodynamic therapy (PDT), used for cancer treatment, is also an alternative method for eradication of drug-resistant bacteria. This method utilizes a nontoxic light-activated dye, called a photosensitizer, and visible light to produce reactive oxygen species that lead to bacterial cell death. The purpose of this study was to investigate the bactericidal effect of PDT using lanthanide derivatives of meso-tetra(N-methyl-4-pyridyl)porphine against Staphylococcus aureus strains. The new photosensitizers appeared to be photodynamically ineffective. No enhancement of antistaphylococcal activity of TMPyP was observed after the conjugation of the porphyrin with lanthanide ions. Additionally, a significant difference in the susceptibility of two bacterial strains to unmodified TMPyP was observed.
Agata Jurczak; Bozena Szramka; Mariusz Grinholc; Janina Legendziewicz; Krzysztof P Bielawski
Related Documents :
23941519 - Attachment of bacterial pathogens to a bacterial cellulose-derived plant cell wall mode...
20399039 - Antibiotic resistance profile of staphylococcus rostri, a new species isolated from hea...
15737479 - Detection of the enterotoxins a, b, and c genes in staphylococcus aureus from goat and ...
1258319 - An investigation into the prevalence of s aureus on avian feet.
17719749 - Activity of staphylococcal bacteriocins against staphylococcus aureus and streptococcus...
15894229 - Staphylococcus aureus: the search for novel targets.
11724869 - Beyond serotypes and virulence-associated factors: detection of genetic diversity among...
25242559 - Alkaline phosphatases and aminopeptidases are altered in a cry11aa resistant strain of ...
7959709 - Reduced uptake and accumulation of norfloxacin in resistant strains of neisseria gonorr...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-08-25
Journal Detail:
Title:  Acta biochimica Polonica     Volume:  55     ISSN:  0001-527X     ISO Abbreviation:  Acta Biochim. Pol.     Publication Date:  2008  
Date Detail:
Created Date:  2008-10-15     Completed Date:  2009-02-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  14520300R     Medline TA:  Acta Biochim Pol     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  581-5     Citation Subset:  IM    
Department of Biotechnology, Intercollegiate Faculty of Biotechnology, Division of Molecular Diagnostics, University of Gdańsk and Medical University of Gdańsk, Gdańsk, Poland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Anti-Bacterial Agents / pharmacology*
Lanthanoid Series Elements / pharmacology
Methicillin-Resistant Staphylococcus aureus / drug effects
Photosensitizing Agents / pharmacology*
Porphyrins / pharmacology*
Staphylococcal Infections / drug therapy
Staphylococcus aureus / drug effects*
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Lanthanoid Series Elements; 0/Photosensitizing Agents; 0/Porphyrins; 38673-65-3/tetra(4-N-methylpyridyl)porphine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The essential function of Swc4p - a protein shared by two chromatin-modifying complexes of the yeast...
Next Document:  Oligoarenes as molecular backbones of catalysts: synthesis and applications.