Document Detail


Photodynamic effect of lanthanide derivatives of meso-tetra(N-methyl-4-pyridyl)porphine against Staphylococcus aureus.
MedLine Citation:
PMID:  18726009     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Photodynamic therapy (PDT), used for cancer treatment, is also an alternative method for eradication of drug-resistant bacteria. This method utilizes a nontoxic light-activated dye, called a photosensitizer, and visible light to produce reactive oxygen species that lead to bacterial cell death. The purpose of this study was to investigate the bactericidal effect of PDT using lanthanide derivatives of meso-tetra(N-methyl-4-pyridyl)porphine against Staphylococcus aureus strains. The new photosensitizers appeared to be photodynamically ineffective. No enhancement of antistaphylococcal activity of TMPyP was observed after the conjugation of the porphyrin with lanthanide ions. Additionally, a significant difference in the susceptibility of two bacterial strains to unmodified TMPyP was observed.
Authors:
Agata Jurczak; Bozena Szramka; Mariusz Grinholc; Janina Legendziewicz; Krzysztof P Bielawski
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-08-25
Journal Detail:
Title:  Acta biochimica Polonica     Volume:  55     ISSN:  0001-527X     ISO Abbreviation:  Acta Biochim. Pol.     Publication Date:  2008  
Date Detail:
Created Date:  2008-10-15     Completed Date:  2009-02-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  14520300R     Medline TA:  Acta Biochim Pol     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  581-5     Citation Subset:  IM    
Affiliation:
Department of Biotechnology, Intercollegiate Faculty of Biotechnology, Division of Molecular Diagnostics, University of Gdańsk and Medical University of Gdańsk, Gdańsk, Poland.
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MeSH Terms
Descriptor/Qualifier:
Anti-Bacterial Agents / pharmacology*
Humans
Lanthanoid Series Elements / pharmacology
Methicillin-Resistant Staphylococcus aureus / drug effects
Photochemotherapy
Photosensitizing Agents / pharmacology*
Porphyrins / pharmacology*
Staphylococcal Infections / drug therapy
Staphylococcus aureus / drug effects*
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Lanthanoid Series Elements; 0/Photosensitizing Agents; 0/Porphyrins; 38673-65-3/tetra(4-N-methylpyridyl)porphine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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