Document Detail


Photodynamic activity of viral nanoparticles conjugated with C60.
MedLine Citation:
PMID:  22858632     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The development of viral nanoparticles (VNP) displaying multiple copies of the buckyball (C(60)) and their photodynamic activity is described. VNP-C(60) conjugates were assembled using click chemistry. Cell uptake and cell killing using white light therapy and a prostate cancer cell line is demonstrated.
Authors:
Amy M Wen; Mary J Ryan; Alice C Yang; Kurt Breitenkamp; Jonathan K Pokorski; Nicole F Steinmetz
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-08-02
Journal Detail:
Title:  Chemical communications (Cambridge, England)     Volume:  48     ISSN:  1364-548X     ISO Abbreviation:  Chem. Commun. (Camb.)     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-08-14     Completed Date:  2012-12-18     Revised Date:  2014-04-23    
Medline Journal Info:
Nlm Unique ID:  9610838     Medline TA:  Chem Commun (Camb)     Country:  England    
Other Details:
Languages:  eng     Pagination:  9044-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Cell Line, Tumor
Click Chemistry
Fullerenes / chemistry*,  pharmacology*
Humans
Photochemotherapy / methods*
Photosensitizing Agents / chemistry*,  pharmacology*
Viruses / chemistry*
Grant Support
ID/Acronym/Agency:
P30 EB011317/EB/NIBIB NIH HHS; R00 EB009105/EB/NIBIB NIH HHS; R00 EB009105/EB/NIBIB NIH HHS; R00 EB011530/EB/NIBIB NIH HHS; T32 EB007509/EB/NIBIB NIH HHS; T32 EB007509/EB/NIBIB NIH HHS
Chemical
Reg. No./Substance:
0/Fullerenes; 0/Photosensitizing Agents; NP9U26B839/fullerene C60
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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