Document Detail


Photodynamic activity of dibiotinylated aluminum sulfophthalocyanine in vitro and in vivo.
MedLine Citation:
PMID:  15963437     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The photodynamic activity of dibiotinylated aluminum sulfophthalocyanine was studied in vitro and in vivo. Dibiotinylated aluminum sulfophthalocyanine provided enhanced phototoxic action on OAT-75 cell monolayers as compared with the parent drug. Photodynamic therapy of mice with Ehrlich carcinoma using dibiotinylated aluminum sulfophthalocyanine (0.25 mg/kg) resulted in enhanced inhibition of tumor growth, pronounced vascular damage (thrombosis and destruction of vascular walls) and eventual tumor necrosis.
Authors:
Irina G Meerovich; Victoriav Jerdeva; Valentina M Derkacheva; Gennady A Meerovich; Eugeny A Lukyanets; Eugenia A Kogan; Alexander P Savitsky
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-04-18
Journal Detail:
Title:  Journal of photochemistry and photobiology. B, Biology     Volume:  80     ISSN:  1011-1344     ISO Abbreviation:  J. Photochem. Photobiol. B, Biol.     Publication Date:  2005 Jul 
Date Detail:
Created Date:  2005-06-20     Completed Date:  2005-12-01     Revised Date:  2007-07-23    
Medline Journal Info:
Nlm Unique ID:  8804966     Medline TA:  J Photochem Photobiol B     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  57-64     Citation Subset:  IM    
Affiliation:
Laboratory of Physical Biochemistry, A.N.Bach Institute of Biochemistry of Russian Academy of Sciences, Leninsky prospect, Moscow.
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MeSH Terms
Descriptor/Qualifier:
Aluminum / pharmacology*,  radiation effects*
Animals
Biotin / analogs & derivatives*,  chemical synthesis,  pharmacology
Biotinylation*
Carcinoma, Small Cell
Cell Line, Tumor
Cell Survival / drug effects,  radiation effects
Humans
Indoles / chemical synthesis*,  pharmacology*
Light
Lung Neoplasms
Mice
Photochemotherapy
Photosensitizing Agents / chemical synthesis,  pharmacology*
Chemical
Reg. No./Substance:
0/Indoles; 0/Photosensitizing Agents; 0/dibiotinylated aluminum sulfophthalocyanine; 58-85-5/Biotin; 7429-90-5/Aluminum

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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