| Photodegradation of 5-methyltetrahydrofolate: biophysical aspects. | |
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MedLine Citation:
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PMID: 16879038 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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5-methyltetrahydrofolate (5MTHF) absorbs UV radiation and has an absorption coefficient of 24250+/-1170 M(-1) cm(-1) at 290 nm. It has a weak fluorescence emission in the wavelength region around 360 nm. Our data demonstrated induction of 5-methyldihydrofolate by exposure to UVB and, after continues irradiation, p-aminobenzoyl-L-glutamic acid was found. The photodegradation of 5MTHF follows a first order kinetic with a degradation rate constant of 9.2 x 10(-3) min(-1) under our conditions (fluence rate of 2.15 mW cm(-2), exposure wavelengths from 280 to 350 nm). Our results indicate that a direct degradation of 5MTHF by UV exposure in humans in vivo is rather unlikely. 5MTHF mainly absorbs, and is degraded by, UVB and UVC, radiation that does not penetrate the earth's atmosphere and the human skin well. |
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Authors:
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Arnfinn Hykkerud Steindal; Asta Juzeniene; Anders Johnsson; Johan Moan |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Photochemistry and photobiology Volume: 82 ISSN: 0031-8655 ISO Abbreviation: Photochem. Photobiol. Publication Date: 2006 Nov-Dec |
Date Detail:
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Created Date: 2007-03-26 Completed Date: 2007-04-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376425 Medline TA: Photochem Photobiol Country: United States |
Other Details:
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Languages: eng Pagination: 1651-5 Citation Subset: IM |
Affiliation:
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Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, N-0310 Oslo, Norway. arnfinn.hykkerud.steindal@rr-research.no |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Folic Acid
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analogs & derivatives*,
chemistry,
radiation effects Methylation Models, Molecular Photochemistry Spectrophotometry, Ultraviolet |
| Chemical | |
Reg. No./Substance:
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59-30-3/Folic Acid; 77921-44-9/5,11-methenyltetrahydrohomofolate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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