Document Detail

Photocytotoxicity of platinum(IV)-chloride surface modified TiO2 irradiated with visible light against murine macrophages.
MedLine Citation:
PMID:  18555693     Owner:  NLM     Status:  MEDLINE    
Phototoxicity of titanium dioxide modified with platinum(IV)-chloride complexes, [TiO2/PtCl4], irradiated with visible light was tested on murine macrophage cell line (RAW 264.7) in vitro. Presence of antioxidants such as alpha-tocopherol or beta-carotene during photodynamic treatment significantly increased cells viability. Our results indicate that observed cell death induced by [TiO2/PtCl4] was due to photogeneration of reactive species.
Agnieszka Jańczyk; Agnieszka Wolnicka-Głubisz; Krystyna Urbanska; Grazyna Stochel; Wojciech Macyk
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-05-13
Journal Detail:
Title:  Journal of photochemistry and photobiology. B, Biology     Volume:  92     ISSN:  1011-1344     ISO Abbreviation:  J. Photochem. Photobiol. B, Biol.     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-07-14     Completed Date:  2008-10-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8804966     Medline TA:  J Photochem Photobiol B     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  54-8     Citation Subset:  IM    
Faculty of Chemistry, Jagiellonian University, Ingardena 3, 30-060 Kraków, Poland.
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MeSH Terms
Cell Line
Macrophages / cytology,  drug effects*,  metabolism,  radiation effects
Platinum Compounds / pharmacology*
Titanium / pharmacology*
alpha-Tocopherol / metabolism*
beta Carotene / metabolism*
Reg. No./Substance:
0/Platinum Compounds; 13454-96-1/platinum tetrachloride; 13463-67-7/titanium dioxide; 59-02-9/alpha-Tocopherol; 7235-40-7/beta Carotene; 7440-32-6/Titanium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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