Document Detail


Photocrosslinked nanocomposite hydrogels from PEG and silica nanospheres: Structural, mechanical and cell adhesion characteristics.
MedLine Citation:
PMID:  23827639     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Photopolymerized hydrogels are extensively investigated for various tissue engineering applications, primarily due to their ability to form hydrogels in a minimally invasive manner. Although photocrosslinkable hydrogels provide necessary biological and chemical characteristics to mimic cellular microenvironments, they often lack sufficient mechanical properties. Recently, nanocomposite approaches have demonstrated potential to overcome these deficits by reinforcing the hydrogel network with. In this study, we investigate some physical, chemical, and biological properties of photocrosslinked poly(ethylene glycol) (PEG)-silica hydrogels. The addition of silica nanospheres significantly suppresses the hydration degree of the PEG hydrogels, indicating surface interactions between the silica nanospheres and the polymer chains. No significant change in hydrogel microstructure or average pore size due to the addition of silica nanospheres was observed. However, addition of silica nanospheres significantly increases both the mechanical strength and the toughness of the hydrogel networks. The biological properties of these nanocomposite hydrogels were evaluated by seeding fibroblast cells on the hydrogel surface. While the PEG hydrogels showed minimum cell adhesion, spreading and proliferation, the addition of silica nanospheres enhanced initial cell adhesion, promoted cell spreading and increased the metabolic activity of the cells. Overall, results indicate that the addition of silica nanospheres improves the mechanical stiffness and cell adhesion properties of PEG hydrogels and can be used for biomedical applications that required controlled cell adhesion.
Authors:
Akhilesh K Gaharwar; Christian Rivera; Chia-Jung Wu; Burke K Chan; Gudrun Schmidt
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Publication Detail:
Type:  Journal Article     Date:  2013-01-08
Journal Detail:
Title:  Materials science & engineering. C, Materials for biological applications     Volume:  33     ISSN:  1873-0191     ISO Abbreviation:  Mater Sci Eng C Mater Biol Appl     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-07-05     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101484109     Medline TA:  Mater Sci Eng C Mater Biol Appl     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1800-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2012. Published by Elsevier B.V.
Affiliation:
Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907-2032, USA. Electronic address: agaharwa@purdue.edu.
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