| Photocrosslinkable starch-based polymers for ophthalmologic drug delivery. | |
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MedLine Citation:
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PMID: 18582497 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study focused on the development and characterization of a starch-based polymer with urethane linkages to be used as a controlled drug delivery system for biomedical applications. Starch was modified with 2-isocyanatoethyl methacrylate in order to obtain a polymer containing carbon-carbon double bonds in its structure. This modified starch was then used to produce films by UV irradiation using Irgacure 2959 (CIBA) as the photoinitiator. The modified polymer was characterized by attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectroscopy. The swelling capacity, in artificial lachrymal fluid (performed both at room temperature and physiological temperature), and water contact angles measurements were determined. The in vitro biodegradation in artificial lachrymal fluid supplemented with lysozyme was also studied. Scanning electronic microscopy (SEM) was used to characterize the morphology of the materials immediately after synthesis and after biodegradation. Timolol maleate and sodium flurbiprofen were immobilized by adsorption and their in vitro release profiles were followed spectroscopically. |
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Authors:
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A P Vieira; P Ferreira; J F J Coelho; M H Gil |
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Publication Detail:
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Type: Journal Article Date: 2008-06-06 |
Journal Detail:
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Title: International journal of biological macromolecules Volume: 43 ISSN: 0141-8130 ISO Abbreviation: Int. J. Biol. Macromol. Publication Date: 2008 Nov |
Date Detail:
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Created Date: 2008-11-21 Completed Date: 2008-12-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7909578 Medline TA: Int J Biol Macromol Country: England |
Other Details:
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Languages: eng Pagination: 325-32 Citation Subset: IM |
Affiliation:
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Chemical Engineering Department, University of Coimbra, Pólo II, Rua Sílvio Lima, 3030-790 Coimbra, Portugal. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adsorption
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drug effects,
radiation effects Cross-Linking Reagents / pharmacology* Drug Delivery Systems* Flurbiprofen / pharmacology Isocyanates / metabolism Methacrylates / metabolism Ophthalmology / methods* Porosity / drug effects, radiation effects Spectroscopy, Fourier Transform Infrared Starch / metabolism*, ultrastructure Temperature Timolol / pharmacology Ultraviolet Rays* Water / chemistry |
| Chemical | |
Reg. No./Substance:
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0/Cross-Linking Reagents; 0/Isocyanates; 0/Methacrylates; 26839-75-8/Timolol; 30674-80-7/2-isocyanatoethyl methacrylate; 5104-49-4/Flurbiprofen; 7732-18-5/Water; 9005-25-8/Starch |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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