Document Detail


Photocrosslinkable starch-based polymers for ophthalmologic drug delivery.
MedLine Citation:
PMID:  18582497     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study focused on the development and characterization of a starch-based polymer with urethane linkages to be used as a controlled drug delivery system for biomedical applications. Starch was modified with 2-isocyanatoethyl methacrylate in order to obtain a polymer containing carbon-carbon double bonds in its structure. This modified starch was then used to produce films by UV irradiation using Irgacure 2959 (CIBA) as the photoinitiator. The modified polymer was characterized by attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectroscopy. The swelling capacity, in artificial lachrymal fluid (performed both at room temperature and physiological temperature), and water contact angles measurements were determined. The in vitro biodegradation in artificial lachrymal fluid supplemented with lysozyme was also studied. Scanning electronic microscopy (SEM) was used to characterize the morphology of the materials immediately after synthesis and after biodegradation. Timolol maleate and sodium flurbiprofen were immobilized by adsorption and their in vitro release profiles were followed spectroscopically.
Authors:
A P Vieira; P Ferreira; J F J Coelho; M H Gil
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Publication Detail:
Type:  Journal Article     Date:  2008-06-06
Journal Detail:
Title:  International journal of biological macromolecules     Volume:  43     ISSN:  0141-8130     ISO Abbreviation:  Int. J. Biol. Macromol.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-11-21     Completed Date:  2008-12-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7909578     Medline TA:  Int J Biol Macromol     Country:  England    
Other Details:
Languages:  eng     Pagination:  325-32     Citation Subset:  IM    
Affiliation:
Chemical Engineering Department, University of Coimbra, Pólo II, Rua Sílvio Lima, 3030-790 Coimbra, Portugal.
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MeSH Terms
Descriptor/Qualifier:
Adsorption / drug effects,  radiation effects
Cross-Linking Reagents / pharmacology*
Drug Delivery Systems*
Flurbiprofen / pharmacology
Isocyanates / metabolism
Methacrylates / metabolism
Ophthalmology / methods*
Porosity / drug effects,  radiation effects
Spectroscopy, Fourier Transform Infrared
Starch / metabolism*,  ultrastructure
Temperature
Timolol / pharmacology
Ultraviolet Rays*
Water / chemistry
Chemical
Reg. No./Substance:
0/Cross-Linking Reagents; 0/Isocyanates; 0/Methacrylates; 26839-75-8/Timolol; 30674-80-7/2-isocyanatoethyl methacrylate; 5104-49-4/Flurbiprofen; 7732-18-5/Water; 9005-25-8/Starch

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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