Document Detail

Photochemically induced ischaemic lesion of the rat sciatic nerve. A novel method providing high incidence of mononeuropathy.
MedLine Citation:
PMID:  8981434     Owner:  NLM     Status:  MEDLINE    
The incidence of behavioural signs of mononeuropathy in rats subjected to chronic constriction injury (CCI) of the sciatic nerve is unpredictable and often low. In the present study, an ischaemic lesion of the rat sciatic nerve was induced photochemically using a low power laser. In these rats tactile allodynia developed with a considerably greater incidence (95%) than in control rats subjected to CCI (45%). The allodynia lasted longer and was more prominent. Responses to thermal stimulation did not markedly differ between the two groups. The ischaemic lesions displayed marked degeneration, particularly of large myelinated fibres. The results suggest that laser irradiation of a peripheral nerve inducing a local photochemical reaction followed by Wallerian degeneration may be a convenient and reproducible experimental method of producing signs of peripheral mononeuropathy.
B Gazelius; J G Cui; M Svensson; B Meyerson; B Linderoth
Related Documents :
10727734 - Myelination in the splenium of the corpus callosum in adult male and female rats.
6740324 - Increased numbers of thoracic dorsal root axons in rats given antibodies to nerve growt...
15529504 - Alterations of the rat temporomandibular joint in functional posterior displacement of ...
24015814 - Transitions between andean and amazonian centers of endemism in the radiation of some a...
6191344 - Comparison of regional brain 5-ht and 5-hiaa content in flexor and extensor rats.
16760904 - Biomarker and drug-target discovery using proteomics in a new rat model of sepsis-induc...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroreport     Volume:  7     ISSN:  0959-4965     ISO Abbreviation:  Neuroreport     Publication Date:  1996 Nov 
Date Detail:
Created Date:  1997-04-01     Completed Date:  1997-04-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9100935     Medline TA:  Neuroreport     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  2619-23     Citation Subset:  IM    
Karolinska Institute Center for Pain Research, Department of Clinical Neuroscience, Karolinska Hospital, Stockholm, Sweden.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Disease Models, Animal
Motor Neuron Disease / pathology*
Rats, Sprague-Dawley
Sciatic Nerve / pathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Non-NMDA receptor-mediated modulation of voltage-activated outward currents in chick neurones.
Next Document:  Memory dysfunction of the frontal type in normal ageing.