Document Detail


Photochemically induced ischaemic lesion of the rat sciatic nerve. A novel method providing high incidence of mononeuropathy.
MedLine Citation:
PMID:  8981434     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The incidence of behavioural signs of mononeuropathy in rats subjected to chronic constriction injury (CCI) of the sciatic nerve is unpredictable and often low. In the present study, an ischaemic lesion of the rat sciatic nerve was induced photochemically using a low power laser. In these rats tactile allodynia developed with a considerably greater incidence (95%) than in control rats subjected to CCI (45%). The allodynia lasted longer and was more prominent. Responses to thermal stimulation did not markedly differ between the two groups. The ischaemic lesions displayed marked degeneration, particularly of large myelinated fibres. The results suggest that laser irradiation of a peripheral nerve inducing a local photochemical reaction followed by Wallerian degeneration may be a convenient and reproducible experimental method of producing signs of peripheral mononeuropathy.
Authors:
B Gazelius; J G Cui; M Svensson; B Meyerson; B Linderoth
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroreport     Volume:  7     ISSN:  0959-4965     ISO Abbreviation:  Neuroreport     Publication Date:  1996 Nov 
Date Detail:
Created Date:  1997-04-01     Completed Date:  1997-04-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9100935     Medline TA:  Neuroreport     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  2619-23     Citation Subset:  IM    
Affiliation:
Karolinska Institute Center for Pain Research, Department of Clinical Neuroscience, Karolinska Hospital, Stockholm, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Animals
Disease Models, Animal
Lasers
Male
Motor Neuron Disease / pathology*
Photochemistry
Rats
Rats, Sprague-Dawley
Sciatic Nerve / pathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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