Document Detail


Photochemical and oxidative degradation of the solid-state tretinoin tocoferil.
MedLine Citation:
PMID:  11310659     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The photostability of tretinoin tocoferil was investigated under irradiation with three kinds of lamps, i.e., a cool white fluorescent lamp, a UV-A fluorescent lamp and a D65 fluorescent lamp. A combination of the cool white fluorescent lamp and the UV-A fluorescent lamp, and the D65 lamp having relative spectral power distribution similar to that of direct daylight, correspond to options 2 and 1 in ICH Guidelines, respectively. The photodegradation apparently followed second-order kinetics under these light sources and the degradation rate constant under exposure by the D65 lamp was larger than that by the cool white fluorescent lamp. The drug was susceptible to degradation by visible and UV light below 480 nm and was degraded most remarkably at around 420 nm, showing a wavelength-dependency. The semi-logarithmic plots of apparent degradation rate constant against the reciprocal of illuminance showed a good linear relationship in the Arrhenius-type fashion, and the photostability under ordinary illumination conditions could be predicted from the data obtained under the accelerated illumination conditions. The rate of oxidative degradation was slightly accelerated with the rise of temperature. Thermodynamic parameter was calculated from the Arrhenius plot. The degradation rate constant rapidly increased in proportion to partial pressure of oxygen below 20 kPa.
Authors:
R Teraoka; Y Konishi; Y Matsuda
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Chemical & pharmaceutical bulletin     Volume:  49     ISSN:  0009-2363     ISO Abbreviation:  Chem. Pharm. Bull.     Publication Date:  2001 Apr 
Date Detail:
Created Date:  2001-04-19     Completed Date:  2001-08-23     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0377775     Medline TA:  Chem Pharm Bull (Tokyo)     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  368-72     Citation Subset:  IM    
Affiliation:
Department of Pharmaceutical Technology, Kobe Pharmaceutical University, Japan. teraoka@kobepharma-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Chemistry, Physical
Chromatography, High Pressure Liquid
Drug Combinations
Light
Oxidation-Reduction
Oxygen / chemistry
Physicochemical Phenomena
Spectrophotometry, Ultraviolet
Temperature
Tretinoin / analogs & derivatives,  chemistry*,  radiation effects
Ultraviolet Rays
Vitamin E / analogs & derivatives,  chemistry*,  radiation effects
Chemical
Reg. No./Substance:
0/Drug Combinations; 1406-18-4/Vitamin E; 302-79-4/Tretinoin; 40516-48-1/tocoretinate; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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