| Photochemical interaction of ascorbic acid with riboflavin, nicotinamide and alpha-tocopherol in cream formulations. | |
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MedLine Citation:
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PMID: 22014159 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The present work is based on a study of the effect of some vitamins such as riboflavin (RF), nicotinamide (NA) and alpha-tocopherol (TP) on the photodegradation of ascorbic acid (vitamin C) (AH(2) ) in oil-in-water cream formulations using a UV irradiation source. A UV spectrophotometric and the official iodimetric methods have been used for the assay of AH(2) in cream formulations. These methods have been validated in the presence of RF, NA and TP before their application to the creams. The recoveries of AH(2) in the creams are in the range of 90-95% and the reproducibility of the method is within ±5%. The apparent first-order rate constants (k(obs) ) for the photodegradation of AH(2) in the presence of RF, NA and TP, individually, in the creams have been obtained. The second-order rate constants for the photochemical interaction of AH(2) and the vitamins RF, NA and TP have been determined from the plots of k(obs) for AH(2) photolysis versus the individual vitamin concentration along with the values of k(0) from the intercept on the vertical axis. The values of k(0) in the presence of RF and NA are lower than those of the k(obs) indicating that these vitamins act as photosensitizers for the degradation of AH(2) in creams. On the contrary, the value of k(0) in the presence of TP is higher than that of the k(obs) suggesting a stabilizing effect of this vitamin on the degradation of AH(2) in creams. The mode of interaction of the individual vitamins with AH(2) on photolysis has been discussed. © 2011 The Authors ICS © 2011 Society of Cosmetic Scientists and the Société Française de Cosmétologie. |
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Authors:
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Iqbal Ahmad; Muhammad Ali Sheraz; Sofia Ahmed; Raheela Bano; Faiyaz H M Vaid |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-20 |
Journal Detail:
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Title: International journal of cosmetic science Volume: - ISSN: 1468-2494 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8007161 Medline TA: Int J Cosmet Sci Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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ICS © 2011 Society of Cosmetic Scientists and the Société Française de Cosmétologie. |
Affiliation:
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Institute of Pharmaceutical Sciences, Baqai Medical University, Toll Plaza, Super Highway, Gadap Road, Karachi-74600, Pakistan Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Karachi-75270, Pakistan. |
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