Document Detail

Photoactivated release of cargo from the cavity of polyelectrolyte capsules to the cytosol of cells.
MedLine Citation:
PMID:  18844388     Owner:  NLM     Status:  MEDLINE    
Polyelectrolyte capsules with metal nanoparticles in their walls and fluorescently labeled polymers as cargo inside their cavity were prepared. Capsules were ingested by living cells with no uncontrolled release of the cargo upon the incorporation process. Photoinduced heating of the metal nanoparticles in the capsule walls lead to rupture of the capsule walls, and the polymeric cargo was released to the whole cytosol. Viability tests demonstrate that opening of capsules at moderate light intensities does not impair the cellular metabolism, whereas capsule opening at high light intensities ultimately leads to cell death.
A Muñoz Javier; P del Pino; M F Bedard; D Ho; A G Skirtach; G B Sukhorukov; C Plank; W J Parak
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-10-10
Journal Detail:
Title:  Langmuir : the ACS journal of surfaces and colloids     Volume:  24     ISSN:  0743-7463     ISO Abbreviation:  Langmuir     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-10-30     Completed Date:  2008-12-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9882736     Medline TA:  Langmuir     Country:  United States    
Other Details:
Languages:  eng     Pagination:  12517-20     Citation Subset:  IM    
Fachbereich Physik, Philipps Universität Marburg, Marburg, Germany.
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MeSH Terms
Cytosol / chemistry*
Electrolytes / chemistry*
Reg. No./Substance:

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