Document Detail


PhotoPoint photodynamic therapy inhibits intimal hyperplasia in arteriovenous access grafts.
MedLine Citation:
PMID:  12974365     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To evaluate the ability of PhotoPoint photodynamic therapy (PDT) to suppress venous anastomotic intimal hyperplasia (IH) in a canine prosthetic arteriovenous graft (AVG) model. METHODS AND MATERIALS: Bilateral femoral AVGs were placed in 12 mongrel dogs. PhotoPoint PDT was optimized by treating venous anastomoses with a fixed dose of photosensitizer (MV6401) followed by varying light doses. Veins were evaluated at 3 days for cell depletion. Other venous anastomoses received the optimal PhotoPoint PDT dose following graft placement and were harvested 1 month later. Histological sections of venous anastomoses were analyzed for intimal thickness, fibrosis, inflammation, necrosis and thrombosis. RESULTS: PhotoPoint PDT resulted in a significant reduction of venous anastomotic intimal thickness. In addition, PhotoPoint PDT tended to reduce the development of fibrosis. All veins were patent at harvest, and there was no evidence of PhotoPoint PDT-related pathologies. CONCLUSIONS: PhotoPoint PDT significantly inhibited the development of venous anastomotic IH. These results suggest that PhotoPoint PDT is feasible and may increase patency rates of synthetic hemodialysis AVGs in the clinic.
Authors:
Jennifer Barton; Heidi Nielsen; Steve Rychnovsky; Michael Farooq; Julie Freischlag; Robert Grove
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cardiovascular radiation medicine     Volume:  3     ISSN:  1522-1865     ISO Abbreviation:  Cardiovasc. Radiat. Med.     Publication Date:    2002 Jul-Dec
Date Detail:
Created Date:  2003-09-16     Completed Date:  2003-12-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888865     Medline TA:  Cardiovasc Radiat Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  147-51     Citation Subset:  IM    
Affiliation:
Miravant Medical Technologies Inc., 336 Bollay Drive, Goleta, CA 93117-5550, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Arteriovenous Shunt, Surgical / adverse effects*
Blood Vessel Prosthesis Implantation / adverse effects*
Disease Models, Animal
Dogs
Female
Femoral Artery / injuries,  radiation effects,  surgery
Hyperplasia / etiology*,  pathology,  prevention & control*
Male
Organometallic Compounds / therapeutic use*
Photochemotherapy*
Photosensitizing Agents / therapeutic use*
Postoperative Complications*
Stents / adverse effects*
Tunica Intima / injuries*,  radiation effects,  surgery*
Chemical
Reg. No./Substance:
0/MV6401; 0/Organometallic Compounds; 0/Photosensitizing Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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