Document Detail


Photo-degradable polyurethane self-assembled nanoparticles for photocontrollable release.
MedLine Citation:
PMID:  22646923     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Light-responsive drug delivery systems are particularly appealing which are capable of releasing an active molecule at the appropriate site and rate. We synthesized a series of photodegradable polymers which can form nanoparticles for drug encapsulation. These particles in aqueous solutions are stable in buffers with different pH or at evaluated temperatures, while light can trigger the crash of particles and the release of encapsulated substances. The release efficiency can reach up to 90 % based on Nile red fluorescence intensity upon 15 min light irradiation. Nanoparticle uptake by phagocytic cells and light-triggered release in cells were observed by fluorescence emission of the hydrolyzed fluorescein diacetate upon photo-induced degradation of these nanoparticles. No significant toxicity of these nanoparticles was found at the concentrations up to 1000 μg/mL before or after light irradiation. Further encapsulation and triggered release of a bioactive model drug (Tagalsin G) was evaluated for RAW 264.7 cells. Tagalsin G encapsulated in nanoparticles did not show cytotoxity to cells, while light triggered the release of Tagalsin G which causes cell death dramatically from 9 % to 67 %. Our model studies show a new promising strategy to trigger drug release in cells.
Authors:
Cong Lv; Zhen Wang; Peng Wang; Xinjing Tang
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-30
Journal Detail:
Title:  Langmuir : the ACS journal of surfaces and colloids     Volume:  -     ISSN:  1520-5827     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-5-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9882736     Medline TA:  Langmuir     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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