Document Detail


Phosphorylated α-synuclein in Parkinson's disease.
MedLine Citation:
PMID:  22344688     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Phosphorylated α-synuclein (PS-129), a protein implicated in the pathogenesis of Parkinson's disease (PD), was identified by mass spectrometry in human cerebrospinal fluid (CSF). A highly sensitive and specific assay was established and used to measure PS-129 together with total α-synuclein in the CSF of patients with PD, other parkinsonian disorders such as multiple system atrophy (MSA) and progressive supranuclear palsy (PSP), and healthy individuals (a total of ~600 samples). PS-129 CSF concentrations correlated weakly with PD severity and, when combined with total α-synuclein concentrations in CSF, contributed to distinguishing PD from MSA and PSP. Further rigorous validation in independent cohorts of patients, especially those where samples have been collected longitudinally, will determine whether the concentration of PS-129 in CSF will be useful for diagnosing PD and for monitoring PD severity and progression.
Authors:
Yu Wang; Min Shi; Kathryn A Chung; Cyrus P Zabetian; James B Leverenz; Daniela Berg; Karin Srulijes; John Q Trojanowski; Virginia M-Y Lee; Andrew D Siderowf; Howard Hurtig; Irene Litvan; Mya C Schiess; Elaine R Peskind; Masami Masuda; Masato Hasegawa; Xiangmin Lin; Catherine Pan; Douglas Galasko; David S Goldstein; Poul Henning Jensen; Hui Yang; Kevin C Cain; Jing Zhang
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Science translational medicine     Volume:  4     ISSN:  1946-6242     ISO Abbreviation:  Sci Transl Med     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-02-20     Completed Date:  2012-07-09     Revised Date:  2014-07-02    
Medline Journal Info:
Nlm Unique ID:  101505086     Medline TA:  Sci Transl Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  121ra20     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Case-Control Studies
Humans
Parkinson Disease / cerebrospinal fluid,  metabolism*
Phosphorylation
alpha-Synuclein / metabolism*
Grant Support
ID/Acronym/Agency:
AG025327/AG/NIA NIH HHS; AG033398/AG/NIA NIH HHS; ES004696-5897/ES/NIEHS NIH HHS; ES007033-6364/ES/NIEHS NIH HHS; NS053488/NS/NINDS NIH HHS; NS057567/NS/NINDS NIH HHS; NS060252/NS/NINDS NIH HHS; NS062684/NS/NINDS NIH HHS; NS065070/NS/NINDS NIH HHS; P30 ES007033-13/ES/NIEHS NIH HHS; P42 ES004696-23S1/ES/NIEHS NIH HHS; P50 NS053488/NS/NINDS NIH HHS; P50 NS053488-05/NS/NINDS NIH HHS; P50 NS062684-04/NS/NINDS NIH HHS; R01 AG025327-01/AG/NIA NIH HHS; R01 AG033398/AG/NIA NIH HHS; R01 AG033398-01/AG/NIA NIH HHS; R01 NS057567-01A2/NS/NINDS NIH HHS; R01 NS065070/NS/NINDS NIH HHS; R01 NS065070-01A1/NS/NINDS NIH HHS; R21 NS060252-01/NS/NINDS NIH HHS; U01 NS082137/NS/NINDS NIH HHS; UL1 TR000423/TR/NCATS NIH HHS
Chemical
Reg. No./Substance:
0/alpha-Synuclein
Comments/Corrections

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