| Phosphorus magnetic resonance spectroscopy: a noninvasive technique for the study of occlusive arterial leg disease and peripheral vasodilator therapy. | |
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MedLine Citation:
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PMID: 8172384 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Using 31P nuclear magnetic resonance spectroscopy of the calf muscle, the authors studied patients with peripheral arterial occlusive disease. They studied PCr depletion and intracellular pH during aerobic exercise in patients and controls. The phosphocreatine (PCr) index ([PCr]/([PCr] + [Pi])) at rest was correlated with blood flow measured by plethysmography. During aerobic exercise a greater decrease in pH was obtained in patients (p < 0.03). They also studied the work necessary to reach a PCr index = 0.5 during ischemic exercise. This workload was lower in patients than in controls: 32.99 +/- 3.04 J vs 58.89 +/- 8.55 J, p < 0.05. After vasodilator therapy the workload was improved in patients: 32.99 +/- 3.04 J vs 38.85 +/- 3.54 J, p < 0.05. These results suggest that therapy resulted in improved tissue perfusion in patients. |
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Authors:
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D G Wahl; J P Simon; B Robin; P Walker; P Jouanny; J M Escanye; F Paille; C Schmidt; F Brunotte; J Robert |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Angiology Volume: 45 ISSN: 0003-3197 ISO Abbreviation: Angiology Publication Date: 1994 May |
Date Detail:
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Created Date: 1994-06-01 Completed Date: 1994-06-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0203706 Medline TA: Angiology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 367-76 Citation Subset: IM |
Affiliation:
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Service de Médecine H, Hôpital Central, Nancy, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Arterial Occlusive Diseases
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drug therapy,
metabolism* Exercise Humans Hydrogen-Ion Concentration Intermittent Claudication / drug therapy, metabolism Ischemia / drug therapy, metabolism Leg / blood supply* Magnetic Resonance Spectroscopy / instrumentation, methods* Middle Aged Oxidative Phosphorylation / drug effects Phosphocreatine / metabolism Phosphorus Radioisotopes Vasodilator Agents / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Phosphorus Radioisotopes; 0/Vasodilator Agents; 67-07-2/Phosphocreatine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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