| Phosphorus-31 magnetic resonance spectroscopy of skeletal muscle in maternally inherited diabetes and deafness A3243G mitochondrial mutation carriers. | |
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MedLine Citation:
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PMID: 19097109 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To investigate high-energy phosphate metabolism in striated skeletal muscle of patients with Maternally Inherited Diabetes and Deafness (MIDD) syndrome. MATERIALS AND METHODS: In 11 patients with the MIDD mutation (six with diabetes mellitus [DM] and five non-DM) and eight healthy subjects, phosphocreatine (PCr) and inorganic phosphate (Pi) in the vastus medialis muscle was measured immediately after exercise using (31)P-magnetic resonance spectroscopy (MRS). The half-time of recovery (t1/2) of monoexponentially fitted (PCr+Pi)/PCr was calculated from spectra obtained every 4 seconds after cessation of exercise. A multiple linear regression model was used for statistical analysis. RESULTS: Patients with the MIDD mutation showed a significantly prolonged t1/2 (PCr+Pi)/PCr after exercise as compared to controls (13.6+/-3.0 vs. 8.7+/-1.3 sec, P = 0.01). No association between the presence of DM and t1/2 (PCr + Pi)/PCr was found (P = 0.382). CONCLUSION: MIDD patients showed impaired mitochondrial oxidative phosphorylation in skeletal muscle shortly after exercise, irrespective of the presence of DM. |
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Authors:
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Saskia G C van Elderen; Joost Doornbos; Einar H R van Essen; Herman H P J Lemkes; J Antonie Maassen; Jan W A Smit; Albert de Roos |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of magnetic resonance imaging : JMRI Volume: 29 ISSN: 1053-1807 ISO Abbreviation: J Magn Reson Imaging Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2008-12-24 Completed Date: 2009-02-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9105850 Medline TA: J Magn Reson Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 127-31 Citation Subset: IM |
Affiliation:
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Department of Radiology, Leiden University Medical Centre, Leiden, The Netherlands. s.g.c.van_elderen@lumc.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Deafness / physiopathology* Diabetes Mellitus / genetics, metabolism, physiopathology* Female Genetic Predisposition to Disease / genetics Heterozygote Humans Magnetic Resonance Spectroscopy Male Mitochondria, Muscle / genetics*, metabolism* Mitochondrial Diseases / physiopathology* Mothers Muscle, Skeletal / metabolism* Mutation Phosphorus / analysis* Phosphorus Isotopes / analysis |
| Chemical | |
Reg. No./Substance:
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0/Phosphorus Isotopes; 7723-14-0/Phosphorus |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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