Document Detail

Phosphorus-31 brain MR spectroscopy in women during and after pregnancy compared with nonpregnant control subjects.
MedLine Citation:
PMID:  15709134     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND PURPOSE: A reversible decrease in brain size has been demonstrated during normal pregnancy that is maximal at term and returns to normal after many months. The purpose of this longitudinal study was to use phosphorus-31 MR spectroscopy to determine if metabolic changes explain this physiologic event. METHODS: Pregnant women (n = 12) were examined at term and up to 6 months after delivery. Nonpregnant control subjects (n = 7) were imaged twice (a month apart) to exclude hormone effects. Brain (31)P MR spectra were acquired at 1.5 T, and intracellular pH was calculated from the chemical shift between phosphocreatine and inorganic phosphate resonances. Statistical analysis was performed by using an analysis of variance. RESULTS: We found no statistically significant differences in the relative levels of metabolite associated with cerebral bioenergetics and cell membrane metabolism between pregnant women and nonpregnant women. However, a significant increase in cerebral pH was observed in pregnant women at 6 weeks after delivery compared with control subjects (7.074 +/- 0.063 vs 7.017 +/- 0.041; P < .05). pH returned to normal by 6 months after delivery (7.014 +/- 0.010). CONCLUSION: Changes in brain size associated with pregnancy appear to be associated with an increase in intracellular pH after delivery. The observed alkalosis may reflect altered cellular metabolism. These persistent brain perturbations associated with pregnancy indicate that, when postpartum physiologic and pharmacologic changes are measured, long-term effects may be expected in central nervous system processing.
Anita Holdcroft; Lisa Hall; Gavin Hamilton; Serena J Counsell; Graeme M Bydder; Jimmy D Bell
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  AJNR. American journal of neuroradiology     Volume:  26     ISSN:  0195-6108     ISO Abbreviation:  AJNR Am J Neuroradiol     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-02-14     Completed Date:  2005-12-22     Revised Date:  2008-02-14    
Medline Journal Info:
Nlm Unique ID:  8003708     Medline TA:  AJNR Am J Neuroradiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  352-6     Citation Subset:  IM    
Department of Anesthesia, MRC Clinical Sciences Centre, Faculty of Medicine, Hammersmith Hospital Campus, Imperial College London, UK.
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MeSH Terms
Brain / metabolism*
Longitudinal Studies
Magnetic Resonance Spectroscopy*
Phosphorus Isotopes / diagnostic use*
Reg. No./Substance:
0/Phosphorus Isotopes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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