Document Detail


Phosphoribosylpyrophosphate in erythrocytes of ten mammalian species: concentration, synthesis and degradation.
MedLine Citation:
PMID:  95678     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. The concentration of PRPP and the activity of PRPP synthetase have been measured in hemolysates from man and nine other mammalian species. PRPP synthetase activity was very low in dog hemolysate. 2. High concentrations of PRPP appeared to be associated with low levels of HGPRT activity, suggesting that HGPRT is the major pathway for utilization of PRPP in mammalian erythrocytes. 3. An alternative catabolic route for PRPP was observed in mammalian hemolysates, which seemed to be associated with acid phosphatase activity. The activity of acid phosphatase in mammalian hemolysates was measured.
Authors:
W J Tax; J H Veerkamp
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Comparative biochemistry and physiology. B, Comparative biochemistry     Volume:  59     ISSN:  0305-0491     ISO Abbreviation:  Comp. Biochem. Physiol., B     Publication Date:  1978  
Date Detail:
Created Date:  1989-06-02     Completed Date:  1989-06-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2984730R     Medline TA:  Comp Biochem Physiol B     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  219-22     Citation Subset:  IM    
Affiliation:
Department of Biochemistry, University of Nijmegen, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Acid Phosphatase / blood
Animals
Erythrocytes / metabolism*
Humans
Hydrogen-Ion Concentration
Hydrolysis
Hypoxanthine Phosphoribosyltransferase / blood
Mammals / blood*
Pentosephosphates / blood*
Phosphoribosyl Pyrophosphate
Ribose-Phosphate Pyrophosphokinase / blood
Species Specificity
Chemical
Reg. No./Substance:
0/Pentosephosphates; 7540-64-9/Phosphoribosyl Pyrophosphate; EC 2.4.2.8/Hypoxanthine Phosphoribosyltransferase; EC 2.7.6.1/Ribose-Phosphate Pyrophosphokinase; EC 3.1.3.2/Acid Phosphatase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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