Document Detail

Phospholipids of normal and experimentally injured spinal cord of the miniature pig.
MedLine Citation:
PMID:  4000399     Owner:  NLM     Status:  MEDLINE    
Experimental spinal cord trauma was produced in 3-month-old SS-1 miniature pigs by dropping a 25 g weight from a height of 20 cm upon the exposed spinal cord. The histological lesion consisted of edema and hemorrhage. Phospholipid concentration and composition, cholesterol concentration and phospholipid fatty acid composition were determined in whole spinal cord 3 hours after injury, and in spinal cord myelin 5 hours after injury. Three hours after injury phospholipid and cholesterol concentration were decreased by about 14% in the whole spinal cord. Trauma had no effect on the phospholipid composition of whole spinal cord and myelin. Fatty acid composition of myelin also did not change after injury, and changed very slightly in the whole spinal cord. It is concluded that edema following spinal cord trauma is much more extensive than previously assumed. Furthermore, peroxidation of membrane lipid fatty acids does not appear to be a significant factor in spinal cord pathology 3 hours after injury.
K Segler-Stahl; P Demediuk; R Castillo; C Watts; E A Moscatelli
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neurochemical research     Volume:  10     ISSN:  0364-3190     ISO Abbreviation:  Neurochem. Res.     Publication Date:  1985 Apr 
Date Detail:
Created Date:  1985-07-23     Completed Date:  1985-07-23     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7613461     Medline TA:  Neurochem Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  563-9     Citation Subset:  IM    
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MeSH Terms
Chemical Phenomena
Cholesterol / analysis
Fatty Acids / analysis
Fatty Acids, Unsaturated / analysis
Myelin Sheath / analysis
Phospholipids / analysis*
Spinal Cord / analysis*
Spinal Cord Injuries / metabolism*
Swine, Miniature
Reg. No./Substance:
0/Fatty Acids; 0/Fatty Acids, Unsaturated; 0/Phospholipids; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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