| Phospholipid transfer protein in hemodialysis patients. | |
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MedLine Citation:
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PMID: 17308375 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: Phospholipid transfer protein (PLTP) is mainly involved in high-density lipoprotein (HDL) metabolism. The role of PLTP in atherogenesis is still controversial. We aimed to investigate PLTP activity in hemodialysis (HD) patients, a population which has an increased risk for the development of atherosclerosis. METHODS: PLTP activity and other markers were analyzed in blood samples from 68 HD patients and in a matched group of 68 healthy controls. RESULTS: Serum PLTP activity was nearly doubled in HD patients in comparison to healthy controls (median 43.0 vs. 22.4 pmol/mul/h, p < 0.001). In HD patients, PLTP activity correlated with HDL-C (r = 0.342, p = 0.004), but not with CRP (r = -0.057, p = 0.644) or leukocyte count (r = 0.116, p = 0.345). After a follow-up of 2 years, 26 HD patients had died. Kaplan-Meier analyses showed that low CRP (p = 0.047) but neither high HDL-C (p = 0.071) nor low PLTP activity (p = 0.853) were relevantly related to survival of HD patients. CONCLUSION: An elevated PLTP activity in HD patients may be considered as a further aspect of uremic dyslipidemia in HD patients. However, PLTP activity was not related to markers of inflammation or to survival of HD patients, even though it correlated with HDL-C. Thus, we conclude that PLTP does not influence the prognostically relevant inflammatory process in HD patients although it does influence the composition of HDL particles. |
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Authors:
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Axel Schlitt; Gunnar H Heine; Xian-Cheng Jiang; Martina Messow; Stefan Blankenberg; Hans J Rupprecht; Christof Ulrich; Michael Buerke; Karl Werdan; Karl J Lackner; Hans Köhler; Matthias Girndt |
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Publication Detail:
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Type: Journal Article Date: 2007-02-16 |
Journal Detail:
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Title: American journal of nephrology Volume: 27 ISSN: 1421-9670 ISO Abbreviation: Am. J. Nephrol. Publication Date: 2007 |
Date Detail:
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Created Date: 2007-04-11 Completed Date: 2007-04-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8109361 Medline TA: Am J Nephrol Country: Switzerland |
Other Details:
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Languages: eng Pagination: 138-43 Citation Subset: IM |
Copyright Information:
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Copyright 2007 S. Karger AG, Basel. |
Affiliation:
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Department of Medicine III, Martin Luther University, Halle-Wittenberg, Germany. axel.schlitt@medizin.uni-halle.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Biological Markers / metabolism Dyslipidemias / metabolism Female Humans Kidney Failure, Chronic / mortality, physiopathology, therapy Lipoproteins, HDL / metabolism* Male Middle Aged Phospholipid Transfer Proteins / blood, metabolism* Prognosis Renal Dialysis* / mortality |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Lipoproteins, HDL; 0/Phospholipid Transfer Proteins |
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