Document Detail


Phospholipid transfer protein in hemodialysis patients.
MedLine Citation:
PMID:  17308375     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: Phospholipid transfer protein (PLTP) is mainly involved in high-density lipoprotein (HDL) metabolism. The role of PLTP in atherogenesis is still controversial. We aimed to investigate PLTP activity in hemodialysis (HD) patients, a population which has an increased risk for the development of atherosclerosis. METHODS: PLTP activity and other markers were analyzed in blood samples from 68 HD patients and in a matched group of 68 healthy controls. RESULTS: Serum PLTP activity was nearly doubled in HD patients in comparison to healthy controls (median 43.0 vs. 22.4 pmol/mul/h, p < 0.001). In HD patients, PLTP activity correlated with HDL-C (r = 0.342, p = 0.004), but not with CRP (r = -0.057, p = 0.644) or leukocyte count (r = 0.116, p = 0.345). After a follow-up of 2 years, 26 HD patients had died. Kaplan-Meier analyses showed that low CRP (p = 0.047) but neither high HDL-C (p = 0.071) nor low PLTP activity (p = 0.853) were relevantly related to survival of HD patients. CONCLUSION: An elevated PLTP activity in HD patients may be considered as a further aspect of uremic dyslipidemia in HD patients. However, PLTP activity was not related to markers of inflammation or to survival of HD patients, even though it correlated with HDL-C. Thus, we conclude that PLTP does not influence the prognostically relevant inflammatory process in HD patients although it does influence the composition of HDL particles.
Authors:
Axel Schlitt; Gunnar H Heine; Xian-Cheng Jiang; Martina Messow; Stefan Blankenberg; Hans J Rupprecht; Christof Ulrich; Michael Buerke; Karl Werdan; Karl J Lackner; Hans Köhler; Matthias Girndt
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Publication Detail:
Type:  Journal Article     Date:  2007-02-16
Journal Detail:
Title:  American journal of nephrology     Volume:  27     ISSN:  1421-9670     ISO Abbreviation:  Am. J. Nephrol.     Publication Date:  2007  
Date Detail:
Created Date:  2007-04-11     Completed Date:  2007-04-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8109361     Medline TA:  Am J Nephrol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  138-43     Citation Subset:  IM    
Copyright Information:
Copyright 2007 S. Karger AG, Basel.
Affiliation:
Department of Medicine III, Martin Luther University, Halle-Wittenberg, Germany. axel.schlitt@medizin.uni-halle.de
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Biological Markers / metabolism
Dyslipidemias / metabolism
Female
Humans
Kidney Failure, Chronic / mortality,  physiopathology,  therapy
Lipoproteins, HDL / metabolism*
Male
Middle Aged
Phospholipid Transfer Proteins / blood,  metabolism*
Prognosis
Renal Dialysis* / mortality
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Lipoproteins, HDL; 0/Phospholipid Transfer Proteins

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