Document Detail


Phospholipid and sphingolipid metabolism in Leishmania.
MedLine Citation:
PMID:  20026359     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In many eukaryotes, phospholipids (PLs) and sphingolipids (SLs) are abundant membrane components and reservoirs for important signaling molecules. In Leishmania, the composition, metabolism, and function of PLs and SLs differ significantly from those in mammalian cells. Although only a handful of enzymes have been experimentally characterized, available data suggest many steps of PL/SL metabolism are critical for Leishmania viability and/or virulence, and could be a source for new drug targets. Further studies of genes involved in the synthesis (de novo and salvage) and degradation of PLs and SLs will reveal their diverse effects on Leishmania pathogenesis.
Authors:
Kai Zhang; Stephen M Beverley
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2009-12-23
Journal Detail:
Title:  Molecular and biochemical parasitology     Volume:  170     ISSN:  1872-9428     ISO Abbreviation:  Mol. Biochem. Parasitol.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-02-01     Completed Date:  2010-03-30     Revised Date:  2013-05-31    
Medline Journal Info:
Nlm Unique ID:  8006324     Medline TA:  Mol Biochem Parasitol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  55-64     Citation Subset:  IM    
Affiliation:
Department of Biological Sciences, Texas Tech University, Lubbock, TX 79409, USA. kai.zhang@ttu.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Biosynthetic Pathways / genetics
Leishmania / genetics,  metabolism*,  pathogenicity,  physiology
Phospholipids / metabolism*
Sphingolipids / metabolism*
Grant Support
ID/Acronym/Agency:
AI31078/AI/NIAID NIH HHS; R01 AI021903-25A1/AI/NIAID NIH HHS; R01 AI029646-20/AI/NIAID NIH HHS; R01 AI031078-17/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Phospholipids; 0/Sphingolipids
Comments/Corrections

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