| Phospholipid metabolism and depression: the possible roles of phospholipase A2 and coenzyme A-independent transacylase. | |
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MedLine Citation:
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PMID: 12404597 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Phospholipids make up 60 per cent of the dry weight of the brain. They are essential for neuronal and especially for synaptic structure and play key roles in the signal transduction responses to dopamine, serotonin, glutamate and acetyl choline. The unsaturated fatty acid components of phospholipids are abnormal in depression, with deficits of eicosapentaenoic acid and other omega-3 fatty acids and excesses of the omega-6 fatty acid arachidonic acid. Correction of this abnormality by treatment with eicosapentaenoic acid improves depression. The fatty acid abnormalities provide a rational explanation for the associations of depression with cardiovascular disease, immunological activation, cancer, diabetic complications and osteoporosis. The abnormalities cannot be explained by diet, although diet may attenuate or exacerbate their consequences. A number of enzyme abnormalities could explain the phenomena: phospholipase A(2), and coenzyme A-independent transacylase are strong candidates. Copyright 2001 John Wiley & Sons, Ltd. |
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Authors:
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David F Horrobin |
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Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: Human psychopharmacology Volume: 16 ISSN: 1099-1077 ISO Abbreviation: Hum Psychopharmacol Publication Date: 2001 Jan |
Date Detail:
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Created Date: 2002-Oct-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8702539 Medline TA: Hum Psychopharmacol Country: - |
Other Details:
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Languages: ENG Pagination: 45-52 Citation Subset: - |
Affiliation:
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Laxdale Research, Kings Park House, Laurelhill Business Park, Stirling, Scotland FK7 9JQ, UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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