Document Detail


Phospholipid fatty acyl spatial distribution in bovine rod outer segment disk membranes.
MedLine Citation:
PMID:  9459584     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The distribution of fatty acids within the phospholipid headgroup classes was investigated as a function of the age/spatial distribution of bovine rod outer segment disk membranes. The disks were separated into subpopulations based upon the cholesterol content in their membranes. Because disk membrane cholesterol content decreases as the disks are apically displaced in the rod outer segment, this separation yields disk subpopulations of different ages and from age-dependent spatial locations within the outer segment. The phospholipids, phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylserine (PS) and phosphatidylinositol (PI), of each of these subpopulations were separated and the fatty acid composition of each was determined. These data indicated that while most of the fatty acids show little or no change with age/spatial location, some pronounced changes can be observed in certain classes. Within the PC class, 16:0 dramatically decreases with disk age while the 22:6 increases with disk age. While the PE class exhibits some fatty acid changes, they are small. The PS class exhibits no significant changes in fatty acid composition. The PI class which constitutes less than 2% of the total phospholipid exhibits age-related changes in each of the fatty acids which could be measured. Most notable of these is an increase in 20:4 as the disks are apically displaced. These changes indicate a remodeling of the disk membranes which may be related to the phototransduction process or to preparation for eventual disk phagocytosis.
Authors:
A D Albert; J E Young; Z Paw
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  1368     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  1998 Jan 
Date Detail:
Created Date:  1998-02-18     Completed Date:  1998-02-18     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  52-60     Citation Subset:  IM    
Affiliation:
Department of Biochemistry, School of Medicine, University at Buffalo (SUNY), NY 14214, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cattle
Cell Membrane / metabolism
Cholesterol / metabolism
Fatty Acids / metabolism*
Phospholipids / metabolism*
Rod Cell Outer Segment / metabolism*
Grant Support
ID/Acronym/Agency:
EY03328/EY/NEI NIH HHS
Chemical
Reg. No./Substance:
0/Fatty Acids; 0/Phospholipids; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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