| Phospholipid fatty acids and neurotoxicity in human neuroblastoma SH-SY5Y cells. | |
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MedLine Citation:
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PMID: 11514074 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The fatty acid composition of phospholipids from differentiated human neuroblastoma SH-SY5Y cells, human and rat brain tissue and rat brain synaptosomes was determined using high pressure liquid chromatography. Comparison of the fatty acid composition of the cells with that derived from brain tissue identified differences in the cells including a profound deficit of docosahexaenoic acid and an elevation of arachidonic acid. The phospholipid fatty acid content could be modified by addition of free fatty acids to the growth medium, and this was shown to influence the susceptibility of the SH-SY5Y cells to the cell death induced by a mitochondrial toxin, 3-nitropropionic acid. |
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Authors:
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L M Reynolds; C F Dalton; G P Reynolds |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Neuroscience letters Volume: 309 ISSN: 0304-3940 ISO Abbreviation: Neurosci. Lett. Publication Date: 2001 Aug |
Date Detail:
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Created Date: 2001-08-21 Completed Date: 2001-12-04 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: Ireland |
Other Details:
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Languages: eng Pagination: 193-6 Citation Subset: IM |
Affiliation:
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Department of Biomedical Science, The University of Sheffield, Sheffield S10 2TN, UK. l.m.reynolds@shef.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arachidonic Acid / pharmacology Cell Death / drug effects, physiology Convulsants / toxicity Docosahexaenoic Acids / pharmacology Dose-Response Relationship, Drug Fatty Acids / toxicity* Humans Neuroblastoma / metabolism*, pathology* Nitro Compounds Phospholipids / toxicity* Propionic Acids / toxicity Rats Synaptosomes / drug effects*, physiology Tumor Cells, Cultured |
| Chemical | |
Reg. No./Substance:
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0/Convulsants; 0/Fatty Acids; 0/Nitro Compounds; 0/Phospholipids; 0/Propionic Acids; 25167-62-8/Docosahexaenoic Acids; 504-88-1/3-nitropropionic acid; 506-32-1/Arachidonic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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