| Phospholipid fatty acids of brain and liver are modified by alpha-tocopherol and dietary fat in growing chicks. | |
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MedLine Citation:
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PMID: 8774221 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dietary fatty acids modify phospholipid fatty acids in brain and liver of growing chickens post-hatching. The effect of vitamin E deficiency on this process is unknown and may be relevant to the pathogenesis of chick nutritional encephalomalacia (NE). Therefore laying hens received a diet low in vitamin E (10 mg alpha-tocopherol/kg feed). Resulting chicks were assigned to nine dietary groups each fed with either oleic (18:1n-9, 58 g/kg), linoleic (18:2n-6, 57 g/kg) or linolenic (18:3n-3, 56 g/kg) acid together with 5. 25 or 125 mg alpha-tocopherol/kg feed. NE affecting the cerebellum only occurred in the group given linoleic acid and 5 mg alpha-tocopherol/kg. In 1-d-old chicks and after 1 and 2 weeks the phospholipid fatty acid composition of liver, cerebrum and cerebellum (additionally after 3 weeks) was determined. The feed fatty acids were incorporated into the liver very efficiently during the first week of life. Unsaturation of liver membranes decreased in the order dietary linolenic > linoleic > oleic acid. In liver, also, the effect of alpha-tocopherol supplementation on phospholipid fatty acids was most pronounced. The unsaturation index increased during deficiency, whereas n-9 fatty acids decreased. In the chicken brain the alterations were delayed and less distinct. The cerebellum phospholipids were rich in n-9 fatty acids and as a whole more saturated in comparison with the cerebrum. Cerebellar unsaturation increased when linolenic or linoleic acid was given. However, NE-producing dietary conditions were not accompanied by specific alterations in cerebellar phospholipid fatty acids due to the alpha-tocopherol content of the diet. Rather the alterations of membrane fatty acids in the liver seem to play a role in the pathogenesis of NE. |
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Authors:
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H Fuhrmann; H P Sallmann |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The British journal of nutrition Volume: 76 ISSN: 0007-1145 ISO Abbreviation: Br. J. Nutr. Publication Date: 1996 Jul |
Date Detail:
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Created Date: 1996-09-27 Completed Date: 1996-09-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372547 Medline TA: Br J Nutr Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 109-22 Citation Subset: IM |
Affiliation:
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Institute of Physiological Chemistry, Hannover Veterinary School, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain / metabolism* Brain Chemistry Chickens / growth & development* Dietary Fats / administration & dosage Encephalomalacia / etiology, metabolism, veterinary Linoleic Acids / administration & dosage, metabolism Linolenic Acids / administration & dosage, metabolism Liver / chemistry, metabolism* Oleic Acids / administration & dosage, metabolism Phospholipids / metabolism* Poultry Diseases / etiology, metabolism Vitamin E Deficiency / complications, metabolism, veterinary* |
| Chemical | |
Reg. No./Substance:
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0/Dietary Fats; 0/Linoleic Acids; 0/Linolenic Acids; 0/Oleic Acids; 0/Phospholipids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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