| Phospholipid exchange proteins in rat intestine. | |
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MedLine Citation:
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PMID: 1250063 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The 105,000 g supernatant and pH 5.1 supernatant fractions from rat intestinal homogenates stimulate phosphatidylcholine exchange between [32P] phosphatidylcholine liposomes and beef heart mitochondria. This active fraction shows the characteristics of a protein. Isoelectric focusing of the intestinal pH 5.1 fraction shows two peaks of phosphatidylcholine exchange activity: one at an acidic pH (4.5-5.3), the other in a basic pH range (8-9). The second peak of activity appears to be a new phospholipid exchange protein. The anatomic distribution of phosphatidylcholine exchange activity in intestine has been investigated. Expressed per mg of protein, phosphatidylcholine exchange activity is higher in mucosa than in the intestinal wall. No significant differences have been found between villi and crypts cells or between jejunal and ileal villi. Futhermore, exchange activity per mg of protein in mucosa is unaffected by fasting or by feeding a high fat or high cholesterol diet. This suggests that phospholipid exchange activity in the absorptive cells is not a rate limiting step in the process of fat absorption. |
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Authors:
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C Lutton; D B Zilversmit |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Lipids Volume: 11 ISSN: 0024-4201 ISO Abbreviation: Lipids Publication Date: 1976 Jan |
Date Detail:
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Created Date: 1976-04-15 Completed Date: 1976-04-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0060450 Medline TA: Lipids Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 16-20 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cattle Ileum / metabolism Intestinal Mucosa / metabolism Intestine, Small / metabolism* Jejunum / metabolism Liposomes / metabolism Liver / metabolism Male Mitochondria, Muscle / metabolism Muscle Proteins / metabolism* Myocardium / metabolism Organ Specificity Phosphatidylcholines / metabolism* Rats |
| Chemical | |
Reg. No./Substance:
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0/Liposomes; 0/Muscle Proteins; 0/Phosphatidylcholines |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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