| Phospholipid and eicosanoid signaling disturbances in schizophrenia. | |
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MedLine Citation:
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PMID: 14623494 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A variety of biochemical, clinical and genetic evidence suggests that phospholipid metabolism may play an aetiological role in schizophrenia. A key piece of evidence is the reduced vasodilatory response of patients with schizophrenia to nicotinic acid (NA). NA causes vasodilation via the activation of phospholipase A2 (PLA2) leading to the release of free fatty acids from membrane phospholipids and the subsequent production of prostaglandins. Insensitivity to NA may be due to a 'block' in the downstream signaling pathway used by the drug to evoke its response. It can be argued that if such an abnormality occurs in neurons, impaired PLA2-dependent signaling could result in altered glutamateric and dopaminergic transmission in such a way as to produce or exacerbate psychotic symptoms. The complimentary finding of increased PLA2 activity in schizophrenia may be an attempt to overcome the signaling block. It is suggested that intervention aimed at increasing the activity of PLA2-dependent signaling systems may be therapeutically useful in the treatment of the illness. |
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Authors:
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Brian M Ross |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Prostaglandins, leukotrienes, and essential fatty acids Volume: 69 ISSN: 0952-3278 ISO Abbreviation: Prostaglandins Leukot. Essent. Fatty Acids Publication Date: 2003 Dec |
Date Detail:
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Created Date: 2003-11-19 Completed Date: 2004-08-11 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8802730 Medline TA: Prostaglandins Leukot Essent Fatty Acids Country: Scotland |
Other Details:
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Languages: eng Pagination: 407-12 Citation Subset: IM |
Affiliation:
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Ness Foundation, UNI Millennium Institute, Ness House, Dochgarroch, IV3 8GY, Inverness, Scotland, UK. brain@hprf.org.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Calcium
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metabolism Eicosanoids / metabolism* Humans Niacin / metabolism Phospholipases A / metabolism Phospholipases A2 Phospholipids / metabolism* Schizophrenia / enzymology, metabolism* Signal Transduction* |
| Chemical | |
Reg. No./Substance:
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0/Eicosanoids; 0/Phospholipids; 59-67-6/Niacin; 7440-70-2/Calcium; EC 3.1.1.-/Phospholipases A; EC 3.1.1.4/Phospholipases A2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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