Document Detail


Phospholipid content and fatty acid composition in the rat heart after chronic diazepam treatment.
MedLine Citation:
PMID:  9706994     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of chronic diazepam treatment (10 mg/kg/day for 180 days) on the fractional distribution and fatty acid composition of heart phospholipids were studied in male Wistar rats. It was found that diazepam treatment increased the content of phosphatidylcholine and cardiolipin in the heart and slightly increased its phosphatidylcholine fraction. There were no significant changes in fatty acid composition after diazepam treatment in heart phospholipids, with the exception of significant decrease of 20:3n-6 and 20:5n-3 fatty acids. Our findings suggest that diazepam, probably through peripheral benzodiazepine binding sites, altered the content of heart cardiolipin and caused changes in the flux of oxidative phosphorylation in the heart.
Authors:
V Ristić; V Tepsić; S R De Luka; S R Vrbaski
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Physiological research / Academia Scientiarum Bohemoslovaca     Volume:  47     ISSN:  0862-8408     ISO Abbreviation:  Physiol Res     Publication Date:  1998  
Date Detail:
Created Date:  1998-10-22     Completed Date:  1998-10-22     Revised Date:  2008-04-02    
Medline Journal Info:
Nlm Unique ID:  9112413     Medline TA:  Physiol Res     Country:  CZECH REPUBLIC    
Other Details:
Languages:  eng     Pagination:  115-8     Citation Subset:  IM    
Affiliation:
Institute for Medical Research, Belgrade, Yugoslavia.
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MeSH Terms
Descriptor/Qualifier:
Animals
Binding Sites / physiology
Cardiolipins / metabolism
Diazepam / pharmacology*
Fatty Acids / analysis*
Heart / drug effects*
Male
Myocardium / chemistry*
Oxidative Phosphorylation / drug effects
Phosphatidylcholines / metabolism
Phospholipids / metabolism*
Rats
Rats, Wistar
Chemical
Reg. No./Substance:
0/Cardiolipins; 0/Fatty Acids; 0/Phosphatidylcholines; 0/Phospholipids; 439-14-5/Diazepam

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