| Phospholipid content and fatty acid composition in the rat heart after chronic diazepam treatment. | |
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MedLine Citation:
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PMID: 9706994 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of chronic diazepam treatment (10 mg/kg/day for 180 days) on the fractional distribution and fatty acid composition of heart phospholipids were studied in male Wistar rats. It was found that diazepam treatment increased the content of phosphatidylcholine and cardiolipin in the heart and slightly increased its phosphatidylcholine fraction. There were no significant changes in fatty acid composition after diazepam treatment in heart phospholipids, with the exception of significant decrease of 20:3n-6 and 20:5n-3 fatty acids. Our findings suggest that diazepam, probably through peripheral benzodiazepine binding sites, altered the content of heart cardiolipin and caused changes in the flux of oxidative phosphorylation in the heart. |
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Authors:
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V Ristić; V Tepsić; S R De Luka; S R Vrbaski |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Physiological research / Academia Scientiarum Bohemoslovaca Volume: 47 ISSN: 0862-8408 ISO Abbreviation: Physiol Res Publication Date: 1998 |
Date Detail:
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Created Date: 1998-10-22 Completed Date: 1998-10-22 Revised Date: 2008-04-02 |
Medline Journal Info:
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Nlm Unique ID: 9112413 Medline TA: Physiol Res Country: CZECH REPUBLIC |
Other Details:
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Languages: eng Pagination: 115-8 Citation Subset: IM |
Affiliation:
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Institute for Medical Research, Belgrade, Yugoslavia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Binding Sites / physiology Cardiolipins / metabolism Diazepam / pharmacology* Fatty Acids / analysis* Heart / drug effects* Male Myocardium / chemistry* Oxidative Phosphorylation / drug effects Phosphatidylcholines / metabolism Phospholipids / metabolism* Rats Rats, Wistar |
| Chemical | |
Reg. No./Substance:
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0/Cardiolipins; 0/Fatty Acids; 0/Phosphatidylcholines; 0/Phospholipids; 439-14-5/Diazepam |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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