Document Detail

Phospholipid composition and [14C]glycerol incorporation into glycerolipids of toad retina and brain.
MedLine Citation:
PMID:  12170587     Owner:  NLM     Status:  MEDLINE    
The phospholipid composition as well as the in vivo [14C]glycerol uptake in lipids was found to be similar in the toad brain and retina. The choroid lipid labeling was markedly different. An in vitro time-course study of [14C]glycerol incorporation in toad retina lipids disclosed that under the conditions of these experiments: (1) retina is able to rapidly synthesize phosphatidic acid from the radioactive precursor; (2) the sequence phosphatidic acid-diacylglycerol-triacylglycerol operates; (3) a high rate of phosphatidylinositol de novo biosynthesis takes place; (4) phosphoglycerides of choline and of ethanolamine are also heavily labeled after a lag period; (5) in vivo labeling profiles resembled those obtained in vitro mainly regarding phosphatidylinositol biosynthesis; and (6) the presence of glycerol kinase in the CNS is suggested.
H E Pascual de Bazán; N G Bazán
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Journal of neurochemistry     Volume:  27     ISSN:  0022-3042     ISO Abbreviation:  J. Neurochem.     Publication Date:  1976 Nov 
Date Detail:
Created Date:  2002-08-12     Completed Date:  2002-08-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985190R     Medline TA:  J Neurochem     Country:  England    
Other Details:
Languages:  eng     Pagination:  1051-7     Citation Subset:  IM    
Instituto de Investigaciones Bioquímicas, Universidad Nacional del Sur Consejo Nacional de Investigaciones Cientificas y Técnicas, 8000 Bahía Blanca, Argentina.
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MeSH Terms
Brain Chemistry*
Bufo arenarum
Carbon Radioisotopes
Choroid / chemistry,  metabolism
Diglycerides / biosynthesis
Glycerides / biosynthesis*
Glycerol / metabolism*,  pharmacokinetics
Phosphatidic Acids / biosynthesis
Phosphatidylcholines / biosynthesis
Phosphatidylethanolamines / biosynthesis
Phosphatidylinositols / biosynthesis
Phospholipids / analysis*
Retina / chemistry,  metabolism*
Triglycerides / biosynthesis
Reg. No./Substance:
0/Carbon Radioisotopes; 0/Diglycerides; 0/Glycerides; 0/Phosphatidic Acids; 0/Phosphatidylcholines; 0/Phosphatidylethanolamines; 0/Phosphatidylinositols; 0/Phospholipids; 0/Triglycerides; 56-81-5/Glycerol

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