Document Detail

Phospholipases of Candida albicans.
MedLine Citation:
PMID:  11766099     Owner:  NLM     Status:  MEDLINE    
Infections due to Candida albicans are frequent and of clinical importance. Especially at a time of increasing organ transplantations, HIV infections, and resistance to antimicrobial agents a profound knowledge of the interaction between C. albicans and host tissue is mandatory. In addition to secreted aspartyl proteinase, dimorphism, cell surface composition, and toxin production phospholipases are a main factor in pathogenicity. Up to the present, many different groups and subgroups of phospholipases have been detected. These different enzymes are related to various types of aggressive and defensive actions. These range from active invasion of host cell tissue to growth control and remodelling of the yeast cell membrane. It is clear that a multiplicity of factors must co-operate to overcome the host's defences. Yet it can be supposed today that phospholipases are one important factor in this complex interaction. Therefore the known phospholipases of C. albicans are described in detail under clinical aspects.
M Niewerth; H C Korting
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Mycoses     Volume:  44     ISSN:  0933-7407     ISO Abbreviation:  Mycoses     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2001-12-18     Completed Date:  2002-02-28     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8805008     Medline TA:  Mycoses     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  361-7     Citation Subset:  IM    
Klinikum der Universität München, Klinik und Poliklinik für Dermatologie und Allergologie, Germany.
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MeSH Terms
Candida albicans / enzymology*,  pathogenicity
Candidiasis / microbiology*

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