Document Detail


Phospholipases A2 in ischemic and toxic brain injury.
MedLine Citation:
PMID:  10905638     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Phospholipases A2 (PLA2s) regulate hydrolysis of fatty acids, including arachidonic acid, from the sn-2 position of phospholipid membranes. PLA2 activity has been implicated in neurotoxicity and neurodegenerative processes secondary to ischemia and reperfusion and other oxidative stresses. The PLA2s constitute a superfamily whose members have diverse functions and patterns of expression. A large number of PLA2s have been identified within the central nervous systems of rodents and humans. We postulated that group IV large molecular weight, cytosolic phospholipase A2 (cPLA2) has a unique role in neurotoxicity associated with ischemic or toxin stress. We created mice deficient in cPLA2 and tested this hypothesis in two injury models, ischemia/reperfusion and MPTP neurotoxicity. In each model cPLA2 deficient mice are protected against neuronal injury when compared to their wild type littermate controls. These experiments support the hypothesis that cPLA2 is an important mediator of ischemic and oxidative injuries in the brain.
Authors:
A Sapirstein; J V Bonventre
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Neurochemical research     Volume:  25     ISSN:  0364-3190     ISO Abbreviation:  Neurochem. Res.     Publication Date:  2000 May 
Date Detail:
Created Date:  2000-12-20     Completed Date:  2000-12-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7613461     Medline TA:  Neurochem Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  745-53     Citation Subset:  IM    
Affiliation:
Anesthesia and Critical Care, Massachusetts General Hospital, Charlestown 02129, USA. sapirste@helix.mgh.harvard.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain Injuries / enzymology*
Brain Ischemia / enzymology*,  etiology
Humans
Mice
Mice, Knockout
Phospholipases A / deficiency,  genetics,  metabolism*
Phospholipases A2
Rodentia
Grant Support
ID/Acronym/Agency:
DK38452/DK/NIDDK NIH HHS; DK39773/DK/NIDDK NIH HHS; NS10828/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
EC 3.1.1.-/Phospholipases A; EC 3.1.1.4/Phospholipases A2

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