| Phospholipase A secreted by Legionella pneumophila destroys alveolar surfactant phospholipids. | |
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MedLine Citation:
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PMID: 10913695 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Destruction of alveolar surfactant phospholipids by bacterial phospholipases is suggested to be a major virulence factor involved in bacterial pneumonia. Since Legionella pneumophila secretes phospholipase A, we analyzed phospholipid degradation in natural bovine surfactant by L. pneumophila. Phospholipids were reduced in amount after incubation with bacteria or culture supernatant of L. pneumophila serogroup 6. Free fatty acids and lysophosphatidylcholine were formed, the latter is known to be highly cytotoxic. Surface tension of surfactant as determined by pulsating bubble surfactometer increased significantly compared to the control. Phospholipase A activity seems to be a powerful agent of legionellae in causing lung disease. |
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Authors:
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A Flieger; S Gongab; M Faigle; H A Mayer; U Kehrer; J Mussotter; P Bartmann; B Neumeister |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: FEMS microbiology letters Volume: 188 ISSN: 0378-1097 ISO Abbreviation: FEMS Microbiol. Lett. Publication Date: 2000 Jul |
Date Detail:
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Created Date: 2000-10-05 Completed Date: 2000-10-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7705721 Medline TA: FEMS Microbiol Lett Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 129-33 Citation Subset: IM |
Affiliation:
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Abteilung für Transfusionsmedizin, Universitätsklinikum Tübingen, Germany. antje.flieger@uni-tuebingen.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cattle Fatty Acids / analysis Legionella pneumophila / enzymology*, growth & development Lysophosphatidylcholines / analysis Magnetic Resonance Spectroscopy Phosphatidylcholines / analysis Phosphatidylglycerols / analysis Phospholipases A / metabolism* Pulmonary Surfactants / analysis, chemistry, metabolism* Surface Tension Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids; 0/Lysophosphatidylcholines; 0/Phosphatidylcholines; 0/Phosphatidylglycerols; 0/Pulmonary Surfactants; EC 3.1.1.-/Phospholipases A |
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