Document Detail

Phospholipase A activity and prostaglandin release from alveolar macrophages exposed to asbestos.
MedLine Citation:
PMID:  7403338     Owner:  NLM     Status:  MEDLINE    
The effect of asbestos (canadian chrysotile B) was studied on macrophages harvested by guinea-pig bronchoalveolar lavage. In short term incubation (3 hrs), asbestos (1 mg) induced a highly significant increase in macrophage phospholipase A activity and prostaglandin synthesis. At lower concentrations of the fibers (10 micrograms and 100 micrograms), no significant change of macrophage activity was noted following our incubation period. The modification by asbestos of membrane integrity and functions is suggested.
P Sirois; M Rola-Pleszczynski; R Bégin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Prostaglandins and medicine     Volume:  5     ISSN:  0161-4630     ISO Abbreviation:  Prostaglandins Med     Publication Date:  1980 Jul 
Date Detail:
Created Date:  1980-10-27     Completed Date:  1980-10-27     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7810330     Medline TA:  Prostaglandins Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  31-7     Citation Subset:  IM    
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MeSH Terms
Asbestos / pharmacology*
Guinea Pigs
Lung / drug effects
Macrophages / drug effects*,  enzymology
Phospholipases / metabolism*
Phospholipases A / metabolism*
Prostaglandins F / secretion*
Reg. No./Substance:
0/Prostaglandins F; 1332-21-4/Asbestos; EC 3.1.-/Phospholipases; EC 3.1.1.-/Phospholipases A

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