Document Detail

Phospholipase D in calcium-regulated exocytosis: lessons from chromaffin cells.
MedLine Citation:
PMID:  19289180     Owner:  NLM     Status:  MEDLINE    
Membrane fusion remains one of the less well-understood processes in cell biology. A variety of mechanisms have been proposed to explain how the generation of fusogenic lipids at sites of exocytosis facilitates secretion in mammalian cells. Over the last decade, chromaffin cells have served as an important cellular model to demonstrate a key role for phospholipase D1 (PLD1) generated phosphatidic acid in regulated exocytosis. The current model proposes that phosphatidic acid plays a biophysical role, generating a negative curvature and thus promoting fusion of secretory vesicles with the plasma membrane. Moreover, multiple signaling pathways converging on PLD1 regulation have been unraveled in chromaffin cells, suggesting a complex level of regulation dependant on the physiological context.
Marie-France Bader; Nicolas Vitale
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2009-03-13
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  1791     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-25     Completed Date:  2009-10-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  936-41     Citation Subset:  IM    
Institut des Neurosciences Cellulaires et Intégratives, Centre National de la Recherche Scientifique UPR-3212 and Université de Strasbourg, Strasbourg, France.
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MeSH Terms
Calcium / metabolism*
Chromaffin Cells / cytology*,  enzymology*
Models, Biological
Phosphatidic Acids / metabolism
Phospholipase D / metabolism*
Reg. No./Substance:
0/Phosphatidic Acids; 7440-70-2/Calcium; EC D

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