Document Detail

Phospholipase D function in Saccharomyces cerevisiae.
MedLine Citation:
PMID:  19416650     Owner:  NLM     Status:  MEDLINE    
Phosphatidylinositol 4,5-bisphosphate-regulated phosphatidylcholine-specific phospholipase D is conserved from yeast to man. The essential role of this enzyme in yeast is to mediate the fusion of Golgi and endosome-derived vesicles to generate the prospore membrane during the developmental program of sporulation, through the production of the fusogenic lipid phosphatidic acid. In addition to recruiting proteins required for fusion, phosphatidic acid is believed to lower the energy barrier to stimulate membrane curvature. During mitotic growth, phospholipase D activity is dispensable unless the major phosphatidylinositol/phosphatidylcholine transfer protein is absent; it also appears to play a nonessential role in the mating signal transduction pathway. The regulation of phospholipase D activity during both sporulation and mitotic growth is still not fully understood and awaits further characterization.
Rima Mendonsa; JoAnne Engebrecht
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2009-01-30
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  1791     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-25     Completed Date:  2009-10-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  970-4     Citation Subset:  IM    
Department of Molecular and Cellular Biology, University of California, Davis, Davis, CA 95616, USA.
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MeSH Terms
Cell Membrane / enzymology
Lipids / biosynthesis
Pheromones / metabolism
Phospholipase D / chemistry,  metabolism*
Saccharomyces cerevisiae / cytology,  enzymology*,  metabolism
Grant Support
Reg. No./Substance:
0/Lipids; 0/Pheromones; EC D

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