Document Detail


Phospholipase A2-mediated hydrolysis of cardiac phospholipids: the use of molecular and transgenic techniques.
MedLine Citation:
PMID:  9546632     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Under pathophysiological conditions, like myocardial ischemia and reperfusion, cardiac phospholipid homeostasis is severely disturbed, resulting in a net degradation of phospholipids and the accumulation of degradation products, such as lysophospholipids and (non-esterified) fatty acids. The derangements in phospholipid metabolism are thought to be involved in the sequence of events leading to irreversible myocardial injury. The net degradation of phospholipids as observed during myocardial ischemia may result from increased hydrolysis and/or reduced resynthesis, while during reperfusion hydrolysis is likely to prevail in this net degradation. Several studies indicate that the activation of phospholipases A2 plays an important role in the hydrolysis of phospholipids. In this review current knowledge regarding the potential role of the different types of phospholipases A2 in ischemia and reperfusion-induced damage is being evaluated. Furthermore, it is indicated how recent advances in molecular biological techniques could be helpful in determining whether disturbances in phospholipid metabolism indeed play a crucial role in the transition from reversible to irreversible myocardial ischemia and reperfusion-induced injury, the knowledge of which could be of great therapeutic relevance.
Authors:
L J De Windt; R S Reneman; G J Van der Vusse; M Van Bilsen
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Molecular and cellular biochemistry     Volume:  180     ISSN:  0300-8177     ISO Abbreviation:  Mol. Cell. Biochem.     Publication Date:  1998 Mar 
Date Detail:
Created Date:  1998-05-21     Completed Date:  1998-05-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0364456     Medline TA:  Mol Cell Biochem     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  65-73     Citation Subset:  IM    
Affiliation:
Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Animals
Humans
Hydrolysis
Myocardial Ischemia / enzymology*,  metabolism
Myocardial Reperfusion
Myocardium / metabolism*
Phospholipases A / genetics,  metabolism*
Phospholipases A2
Phospholipids / metabolism*
Transgenes
Chemical
Reg. No./Substance:
0/Phospholipids; EC 3.1.1.-/Phospholipases A; EC 3.1.1.4/Phospholipases A2

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