Document Detail

Phosphoinositides in cell regulation and membrane dynamics.
MedLine Citation:
PMID:  17035995     Owner:  NLM     Status:  MEDLINE    
Inositol phospholipids have long been known to have an important regulatory role in cell physiology. The repertoire of cellular processes known to be directly or indirectly controlled by this class of lipids has now dramatically expanded. Through interactions mediated by their headgroups, which can be reversibly phosphorylated to generate seven species, phosphoinositides play a fundamental part in controlling membrane-cytosol interfaces. These lipids mediate acute responses, but also act as constitutive signals that help define organelle identity. Their functions, besides classical signal transduction at the cell surface, include regulation of membrane traffic, the cytoskeleton, nuclear events and the permeability and transport functions of membranes.
Gilbert Di Paolo; Pietro De Camilli
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Nature     Volume:  443     ISSN:  1476-4687     ISO Abbreviation:  Nature     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-10-12     Completed Date:  2006-11-09     Revised Date:  2012-06-26    
Medline Journal Info:
Nlm Unique ID:  0410462     Medline TA:  Nature     Country:  England    
Other Details:
Languages:  eng     Pagination:  651-7     Citation Subset:  IM    
Department of Pathology and Cell Biology, The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, New York, New York 10032, USA.
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MeSH Terms
Cell Membrane / metabolism*
GTP Phosphohydrolases / metabolism
Golgi Apparatus / metabolism
Phosphatidylinositols / metabolism*
Signal Transduction*
Grant Support
Reg. No./Substance:
0/Phosphatidylinositols; EC 3.6.1.-/GTP Phosphohydrolases

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