Document Detail

Phosphohexose isomerase in cerebrospinal fluid in meningitis.
MedLine Citation:
PMID:  7408913     Owner:  NLM     Status:  MEDLINE    
The diagnostic value of determining phosphohexose isomerase (PHI, E.C. activity in the CSF for differential diagnosis of bacterial and viral meningitis was investigated. In 29 patients with untreated bacterial meningitis, a mean enzyme activity of 511 U/1 was found, whereas a value 19 U/1 was found in 61 cases of viral meningitis. The reference range with an upper limit of 6 U/1 was determined from CSF samples from 163 "healthy" children. The high diagnostic sensitivity and specificity of 100% and 99.5% respectively make PHI a sensitive differential diagnostic parameter in meningitis.
D Mathias
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of pediatrics     Volume:  134     ISSN:  0340-6199     ISO Abbreviation:  Eur. J. Pediatr.     Publication Date:  1980 Jun 
Date Detail:
Created Date:  1980-11-20     Completed Date:  1980-11-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7603873     Medline TA:  Eur J Pediatr     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  75-8     Citation Subset:  IM    
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MeSH Terms
Bacterial Infections / diagnosis
Child, Preschool
Diagnosis, Differential
Glucose-6-Phosphate Isomerase / cerebrospinal fluid*
Infant, Newborn
Meningitis / cerebrospinal fluid*,  diagnosis
Reference Values
Virus Diseases / diagnosis
Reg. No./Substance:
EC Isomerase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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