Document Detail


Phosphoglucomutase genetic polymorphism of newborns.
MedLine Citation:
PMID:  11466970     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An association of the phosphoglucomutase locus 1 (PGM1) genetic polymorphism with repeated spontaneous abortion (RSA), with intrauterine development in both normal and diabetic pregnancies, and with fertility has been reported in previous studies. In view of the evolutionary interest and of a possible clinical relevance of PGM1 selection during intrauterine life, this study considers healthy puerperae, consecutive newborns, and couples with RSA as well as two alleles (PGM1*1 and PGM1*2). The joint maternal-neonatal PGM1 distribution in a sample from an Italian rural population is significantly different from that expected assuming Hardy-Weinberg conditions for equilibrium. Deviation is dependent on maternal age and parity. The joint mother-newborn PGM1 genotype distribution is significantly associated with a positive history of previous spontaneous miscarriage, suggesting that the presence of the PGM1*2 allele in the father predisposes to spontaneous abortion. This hypothesis is also supported by the observation that in couples with RSA, the delivery of a live born infant within 5 years from the first episode of miscarriage is negatively associated with the presence of a PGM1*2 allele in the husband. Altogether these observations suggest the hypothesis of PGM1 maternal selection at the reproductive level involving a differential role of PGM1*1 and PGM1*2 alleles of paternal origin.
Authors:
F Gloria-Bottini; N Lucarini; R Palmarino; M La Torre; M Nicotra; P Borgiani; E Cosmi; E Bottini
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of human biology : the official journal of the Human Biology Council     Volume:  13     ISSN:  1042-0533     ISO Abbreviation:  Am. J. Hum. Biol.     Publication Date:    2001 Jan-Feb
Date Detail:
Created Date:  2001-07-24     Completed Date:  2001-08-09     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8915029     Medline TA:  Am J Hum Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  9-14     Citation Subset:  IM    
Affiliation:
Chair of Preventive and Social Pediatrics, University of Rome Tor Vergata School of Medicine, Rome, Italy. bottini@med.uniroma2.it
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MeSH Terms
Descriptor/Qualifier:
Abortion, Habitual / enzymology*,  epidemiology,  genetics*
Adult
Case-Control Studies
Evolution
Genetics, Population
Genotype
Heterozygote
Humans
Italy / epidemiology
Linear Models
Maternal Age
Parity
Phosphoglucomutase*
Phosphoproteins / genetics*
Polymorphism, Genetic / genetics*
Rural Health
Selection, Genetic
Chemical
Reg. No./Substance:
0/Phosphoproteins; EC 5.4.2.2/PGM1 protein, human; EC 5.4.2.2/Phosphoglucomutase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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